Bioabsorbable wound dressing

• US 7,041,868 B2
• Filed: 12/19/2001
• Issued: 05/09/2006
• Est. Priority Date: 12/29/2000
• Status: Expired due to Term

• Current Assignee: Avent Incorporated (Avanos Medical, Inc.)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Malik, Sohail, Soerens, Dave A., Greene, Sharon L., Ambrosio, Archel A., Matthews Kaylor, Rosann M.
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): TRUONG, LINH T
• Application Number:
  US10/026,292
• Publication Number:
  US 20020111576A1
• Time in Patent Office: 1,602 Days
• Field of Search: 424/444, 424/443, 424/445, 602 41- 59, 604305-308
• US Class Current: 602/48
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 13/023 wound covering film layers without a fluid retention layer
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body

Abstract

A wound dressing includes a first layer located adjacent the wound and which comprises a material that is bioabsorbable, porous and adapted for serving as a scaffold for cell attachment and proliferation; and a second layer which is in contact with the first layer and which comprises an absorbent, gel forming material adapted for serving as a barrier to cell adhesion and penetration. A method of treating a wound with the dressing is also disclosed.

Claims

1. A wound dressing comprising:

(a) a first layer located adjacent the wound and which comprises a fibrous nonwoven material that is bioabsorbable, has pores in the range of 50-400 microns in size, and is adapted for serving as a scaffold for cell attachment and proliferation; and

(b) a second layer which is in contact with the first layer and which comprises an absorbent, gel forming material adapted for serving as a barrier to cell adhesion and penetration.

2. The dressing according to claim 1, comprising, in addition,

(c) a third layer which is in contact with the second layer and which comprises a material that is penetrable to vapor but acts as a barrier to the transmission of liquid and microorganisms.

3. The dressing according to claim 1, wherein the fibers that are present in the nonwoven material are melt-spun fibers.

4. The dressing according to claim 3, wherein the melt-spun fibers are fabricated by a method selected from the group consisting of bonded carded web, spunbond and meltblown.

5. The dressing according to claim 1, wherein the material that is bioabsorbable, porous and is adapted for serving as a scaffold for cell attachment and proliferation comprises a material selected from the group consisting of poly(lactic acid), poly(glycolic acid), copolymers of lactic and glycolic acids, poly(ether-co-esters), poly(hydroxybutyrate), copolymers of lactic acid and ε

-aminocapronic acid, lactide polymers, copolymers of poly(hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid, cross-linked hyaluronic acid and cross-linked collagen.

6. The dressing according to claim 5, wherein the bioabsorbable scaffold material is capable of being bioabsorbed within a period of from about 1 week to about 6 months.

7. The dressing according to claim 6, wherein the bioabsorbable scaffold material is capable of being bioabsorbed within a period of from about 1 month to about 2 months.

8. The dressing according to claim 5, wherein the first layer comprises in addition at least one material selected from the group consisting of a hyaluronan, collagen, laminin, fibronectin, growth factor, integrin, sodium hyaluronate, chitosan, niasinamide ascorbate, drug, vitamin, therapeutic peptide, and combinations thereof.

9. The dressing according to claim 6, where the first layer is from about 1 mm to about 10 mm in thickness.

10. The dressing according to claim 9, where the first layer is from about 1 mm to about 2 mm in thickness.

11. The dressing according to claim 1, wherein the absorbent, gel forming material adapted for avoiding cell adhesion and penetration comprises a hydrogel.

12. The dressing according to claim 11, wherein the absorbent, gel forming material has pores that are less than about 10 microns in size when said material is in a hydrated state.

13. The dressing according to claim 12, wherein the absorbent, gel-forming material is selected from a group that consists of polyacrylate hydrogels, polyurethane hydrogels, cross-linked poly(ethylene oxide) hydrogels, carboxymethylcellulose hydrogels, and hydrocolloid type materials.

14. The dressing according to claim 11, wherein the second layer comprises in addition a material selected from the group consisting of vitamins, proteins, peptides, growth factors, drugs, nutrients, antibiotics, and any combination thereof.

15. The dressing of claim 1, having in addition an adhesive, breathable film of a material that can transmit liquid but which is adapted for serving as a barrier to cell adhesion and penetration located between the first layer and the second layer.

19. The dressing of claim 1, having in addition a coating or film of a polymeric material that acts as a barrier to cell growth and can transmit water, but that will slowly dissolve under the conditions of the wound site, which coating or film is located between the first layer and the second layer.

16. A wound dressing comprising:

(a) a first layer located adjacent the wound and which comprises a material that is bioabsorbable, porous and adapted for serving as a scaffold for cell attachment and proliferation;

(b) a second layer comprising a transparent film of a breathable material that can transport liquid peripherally to the edges of said second layer, but which is adapted for serving as a barrier to cell adhesion and penetration; and

(c) a third layer which is in contact with the second layer and which comprises an absorbent material.

17. The dressing according to claim 16, wherein the third layer is located on the periphery of the second layer so that the portion of the second layer that is located over the wound is not covered by the third layer.

18. The dressing according to claim 16, wherein the third layer is in the form of a net having areas through which portions of the second layer that are located over the wound are not covered by the third layer.

20. A method for treating a wound comprising applying to the wound a wound dressing comprising:

(a) a first layer located adjacent the wound and which comprises a fibrous nonwoven material that is bioabsorbable, has pores in the range of 50-400 microns in size, and is adapted for serving as a scaffold for cell attachment and proliferation; and

(b) a second layer which is in contact with the first layer and which comprises an absorbent, gel forming material adapted for serving as a barrier to cell adhesion and penetration.

21. The method according to claim 20, wherein the dressing comprises, in addition,

(c) a third layer which is in contact with the second layer and which comprises a material that is penetrable to vapor but acts as a barrier to the transmission of liquid and microorganisms.

22. A method for treating a wound comprising applying to the wound a wound dressing comprising a layer located adjacent the wound which comprises a nonwcven fabric having pores of from about 50 microns to about 400 microns in size and comprising a material selected from the group consisting of poly(lactic acid), poly(glycolic acid), copolymers of lactic and glycolic acids, poly(ether-co-esters), poly(hydroxybutyrate), copolymers of lactic acid and ε

-aminocapronic acid, lactide polymers, copolymers of poly(hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid, and cross-linked hyaluronic acid.

23. A method for treating a wound comprising applying to the wound a wound dressing comprising:

(a) a first layer located adjacent the wound and which comprises a nonwoven fabric having pores of from about 50 microns to about 400 microns in size and comprising a material selected from the group consisting of poly(lactic acid), poly(glycolic acid), copolymers of lactic and glycolic acids, poly(ether-co-esters), poly(hydroxybutyrate), copolymers of lactic acid and ε

-aminocapronic acid, lactide polymers, copolymers of poly(hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid, cross-linked hyaluronic acid and cross-linked collagen;

(b) a second layer which is in contact with the first layer and which comprises a hydrogel having pores of less than about 10 microns in size when the hydrogel is in a hydrated state; and

(c) third layer which is in contact with the second layer and which comprises a material that is penetrable to vapor but acts as a barrier to the transmission of liquid and microorganisms.