Transgenic transchromosomal rodents for making human antibodies
First Claim
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1. A transgenic mouse comprising two human immunoglobulin loci, wherein one of said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus;
- wherein the human heavy chain locus is carried by transchromosome SC20 and the human light chain locus is carried by a transgene integrated into the genome of said mouse; and
wherein an endogenous mouse heavy chain locus and at least one endogenous mouse light chain locus are inactivated.
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Abstract
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
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4 Claims
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1. A transgenic mouse comprising two human immunoglobulin loci, wherein one of said human immunoglobulin loci is a human heavy chain locus and the other locus is a human light chain locus;
- wherein the human heavy chain locus is carried by transchromosome SC20 and the human light chain locus is carried by a transgene integrated into the genome of said mouse; and
wherein an endogenous mouse heavy chain locus and at least one endogenous mouse light chain locus are inactivated. - View Dependent Claims (2, 3, 4)
- wherein the human heavy chain locus is carried by transchromosome SC20 and the human light chain locus is carried by a transgene integrated into the genome of said mouse; and
Specification