Method and apparatus for selecting inlets of a multiple inlet FAIMS

• US 7,041,969 B2
• Filed: 03/02/2005
• Issued: 05/09/2006
• Est. Priority Date: 03/03/2004
• Status: Expired due to Fees

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Ionalytics Corp. (Thermo Fisher Scientific Incorporated)
• Inventors: Thekkadath, Govindanunny, Guevremont, Roger, Skotnicki, Greg
• Primary Examiner(s): Wells, Nikita
• Assistant Examiner(s): Hashmi, Zia R.
• Application Number:
  US11/068,764
• Publication Number:
  US 20050194527A1
• Time in Patent Office: 433 Days
• Field of Search: None
• US Class Current: 250/285
• CPC Class Codes: G01N 27/624 Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• CPC Class Codes: H01J 49/067 Ion lenses, apertures, skimmers

Abstract

An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.

Claims

1. An apparatus for selecting between a first ion inlet orifice and a second ion inlet orifice of a FAIMS device, comprising:

a first electrode defining a first ion inlet orifice within a first portion thereof, and defining a second ion inlet orifice within a second portion thereof;

a second electrode disposed in a spaced-apart relationship with the first electrode, a space between the first electrode and the second electrode defining a FAIMS analyzer region;

at least a cover for selectably covering the first ion inlet orifice and the second ion inlet orifice, the at least a cover larger than either the first ion inlet orifice or the second ion inlet orifice and providing for uncovering of a substantial area about the first ion inlet orifice and the second ion inlet orifice; and

,

an actuator interface for being driven by an actuator and for moving the at least a cover from a first position in which the first ion inlet orifice is uncovered by the at least a cover and the second ion inlet orifice is covered by a first portion of the at least a cover, to a second other position in which the second ion inlet orifice is uncovered by the at least a cover and the first ion inlet orifice is covered by a second portion of the at least a cover.

2. An apparatus according to claim 1, comprising an actuator coupled to the actuator interface, the actuator for driving the actuator interface.

3. An apparatus according to claim 2, wherein the actuator is a rotating actuator.

4. An apparatus according to claim 1, wherein the at least a cover comprises a first cover member containing the first portion of the at least a cover and a second cover member distinct from the first cover member and containing the second portion of the at least a cover.

5. An apparatus according to claim 4, wherein the first cover member and the second cover member are fabricated from an electrically insulating material.

6. An apparatus according to claim 4, wherein the first cover member and the second cover member are fabricated from an electrically conductive material.

7. An apparatus according to claim 1, comprising a coupling mechanism disposed between the actuator interface and the at least a cover, for moving simultaneously the first portion of the at least a cover and the second portion of the at least a cover.

8. An apparatus for selecting between a first ion inlet orifice and a second ion inlet orifice of a FAIMS device, comprising:

a first electrode defining within a first portion thereof a first ion inlet orifice having first dimensions, and defining within a second portion thereof a second ion inlet orifice having second dimensions;

a second electrode disposed in a spaced-apart relationship with the first electrode, a space between the first electrode and the second electrode defining a FAIMS analyzer region;

at least a cover, comprising;

a first cover portion for covering the first ion inlet orifice when the at least a cover is in a first position and displaceable by an amount that is sufficient for uncovering a substantial area about the first ion inlet orifice when the cover is in a second position;

a second cover portion for covering the second ion inlet orifice when the at least a cover is in the second position and displaceable by an amount that is sufficient for uncovering a substantial area about the second ion inlet orifice when the cover is in the first position; and

,

an actuator interface for being driven by an actuator and for moving the at least a cover from the first position to the second position.

9. An apparatus according to claim 8, comprising an actuator coupled to the actuator interface, the actuator for driving the actuator interface.

10. An apparatus according to claim 9, wherein the actuator is a rotating actuator.

11. An apparatus according to claim 8, wherein the first cover portion is displaceable by an amount that is large relative to the first dimensions, and the second cover portion is displaceable by an amount that is large relative to the second dimensions.

12. A method of selecting between a first ion inlet orifice and a second ion inlet orifice of a FAIMS device, comprising:

providing a FAIMS device comprising a first electrode and a second electrode, the first electrode and the second electrode disposed in a spaced apart arrangement and defining a FAIMS analyzer region therebetween, the FAIMS device comprising a first ion inlet orifice defined within a first portion of the first electrode and a second ion inlet orifice defined within a second portion of the first electrode;

providing a rotating actuator; and

,

in response to rotation of the rotating actuator in a first direction, uncovering the first ion inlet orifice and covering the second ion inlet orifice, wherein the first ion inlet orifice is covered over a first range of rotational orientations of the rotating actuator and is uncovered over a second range of rotational orientations of the rotating actuator, such that accurate rotational alignment of the rotating actuator is obviated.

13. A method according to claim 12, comprising in response to rotation of the rotating actuator in a second direction opposite the first direction, covering the first ion inlet orifice and uncovering the second ion inlet orifice.

14. A method according to claim 13, wherein the second ion inlet orifice is uncovered over the first range of rotational orientations of the rotating actuator and is covered over the second range of rotational orientations of the rotating actuator.

15. A method according to claim 13, comprising translating rotational motion of the rotating actuator into a sliding motion of a cover element relative to the first electrode.

16. A method according to claim 15, wherein covering the first ion inlet orifice comprises forming a substantially gas-tight seal between the cover element and the first electrode about a periphery of the first ion inlet orifice.

17. A method according to claim 12, comprising providing a cover element, the cover element not having an opening defined therethrough that is dimensioned about the same as the first ion inlet orifice for being aligned with the first ion inlet orifice so as to uncover the first ion inlet orifice.

18. A method according to claim 12, comprising providing a cover element disposed adjacent to the first electrode and moveable between a first position in which the first ion inlet orifice is covered and a second position in which the first ion inlet orifice is uncovered.

19. A method according to claim 18, wherein movement of the rotating actuator through the second range of rotational orientations translates into movement of the cover element by an amount that is large relative to at least a dimension of the first ion inlet orifice.