Recombinant fusion proteins to growth hormone and serum albumin
First Claim
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1. A method of producing a fusion protein of serum albumin and growth hormone comprising:
- (a) expressing from a host cell said fusion protein, wherein said host cell comprises a PRB1 promoter element operatively associated with a polynucleotide encoding said fusion protein; and
(b) recovering said protein.
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Abstract
The invention describes methods of producing fusion proteins of albumin and growth hormone and products obtained by the methods.
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Citations
25 Claims
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1. A method of producing a fusion protein of serum albumin and growth hormone comprising:
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(a) expressing from a host cell said fusion protein, wherein said host cell comprises a PRB1 promoter element operatively associated with a polynucleotide encoding said fusion protein; and (b) recovering said protein. - View Dependent Claims (2, 3, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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4. A method of producing a fusion protein of serum albumin and growth hormone comprising:
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(a) expressing from a host cell said fusion protein, wherein said host cell comprises a polynucleotide encoding said fusion protein operatively associated with a S. cerevisiae ADH1 termination sequence; and (b) recovering said protein. - View Dependent Claims (5, 6)
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10. A method of producing a fusion protein of serum albumin and growth hormone comprising:
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(a) expressing from a host cell said fusion protein, wherein said host cell comprises a PRB1 promoter element and S. cerevisiae ADH1 termination sequence operatively associated with a polynucleotide encoding;
(1) an HSA/MFα
-1 hybrid leader sequence and (2) said fusion protein; and(b) recovering said protein.
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Specification