Intrinsically bactericidal absorbent dressing and method of fabrication

• US 7,045,673 B1
• Filed: 12/08/1999
• Issued: 05/16/2006
• Est. Priority Date: 12/08/1998
• Status: Expired due to Fees

• Current Assignee: Quick-Med Technologies Inc, University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: Quick-Med Technologies Inc, University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Batich, Christopher D., Olderman, Gerald M., Schultz, Gregory, Lerner, David S., Mast, Bruce A
• Primary Examiner(s): Lewis, Kim M.
• Application Number:
  US09/857,906
• Time in Patent Office: 2,351 Days
• Field of Search: 602 41- 59, 424441-449, 604304-308, 128/888, 128/889
• US Class Current: 602/48
• CPC Class Codes: A61F 13/0209 comprising superabsorbent material
• CPC Class Codes: A61F 13/8405 Additives, e.g. for odour, disinfectant or pH control

Abstract

Absorbent dressings, including highly-absorbent dressings having antimicrobial polymer attached thereto via non-siloxane bonds are disclosed. Bandages (i.e. wound dressing), sanitary napkins and the like are useful applications for the intrinsically bactericidal absorbent dressings whose method of manufacture and use are disclosed and claimed.

Claims

1. An intrinsically antimicrobial material comprising:

an absorbent polymeric matrix having an enhanced surface area;

wherein said enhanced surface area further comprises a polymer of antimicrobial monomeric moieties attached to said matrix via non-siloxane covalent chemical bonds so as to result in a structure which is less prone to degradation by acids or bases produced during bacterial growth and consequent detachment of said polymer of antimicrobial monomeric moieties from the matrix, whereby the material remains antimicrobial after exposure of the material to skin or aqueous biological fluids.

2. The material of claim 1, wherein said aqueous biological fluids are bodily fluids, sweat, tears, mucus, urine, menses, blood, wound exudates, or mixtures thereof.

3. The material of claim 1, wherein molecules of said polymer are attached to said matrix via one or more covalent carbon-oxygen-carbon bonds, or carbon-carbon bonds, or carbon-nitrogen bonds, or combinations thereof.

4. The material of claim 1, wherein said antimicrobial monomeric moieties are allyl- or vinyl-containing monomers.

5. The material of claim 1, wherein said antimicrobial monomeric moieties comprise at least one quaternary ammonium compound.

6. The material of claim 5, wherein the quaternary ammonium compound is dimethyldiallyl ammonium chloride, or a trialkyl(p-vinylbenzyl)ammonium chloride, or a p-trialkylaminoethyl styrene monomer.

7. The material of claim 1, wherein said matrix comprises cellulose.

8. The material of claim 1, wherein said matrix comprises a polyethylene oxide, a polyvinyl alcohol, or a polyacrylate.

9. The material of claim 1, wherein said matrix consists essentially of hydrophilic fibers or filaments having a superabsorbent capacity for aqueous biological fluids as evidenced by being capable of absorbing at least about thirty times its own weight of water.

10. An absorbent dressing, diaper, sanitary pad, or tampon comprising the intrinsically antimicrobial material of claim 1.

11. A method for fabricating the intrinsically antimicrobial material of claim 9 comprising the steps of:

forming an absorbent polymeric matrix having an enhanced surface area; and

attaching a polymer of antimicrobial monomeric moieties in an amount sufficient to impart to the material an antimicrobial effect which remains after exposure of the material to skin or aqueous biological fluids.

12. The method of claim 11, wherein said antimicrobial monomeric moieties comprise at least one quaternary ammonium compound.

13. The method of claim 12, wherein the quaternary ammonium compound is dimethyldiallyl ammonium chloride, or a trialkyl(p-vinylbenzyl)ammonium chloride, or a p-trialkylaminoethyl styrene monomer.