Method of localizing the myocardium of the heart and method of determining perfusion parameters thereof

• US 7,047,061 B2
• Filed: 12/05/2001
• Issued: 05/16/2006
• Est. Priority Date: 12/05/2000
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Breeuwer, Marcel
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US10/012,024
• Publication Number:
  US 20020087072A1
• Time in Patent Office: 1,623 Days
• Field of Search: 600/410, 600/420, 600/419, 324/306, 324/309, 324/307, 382/128, 382/266, 382/131, 128/920, 128/922
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G06T 2207/30048 Heart; Cardiac
• CPC Class Codes: G06T 7/66 of image moments or centre of gravity

Abstract

The invention relates to a method of deriving the myocardial region from one or more MR images. Left and right ventricle contours (1, 2) are determined. The thickness or width (D) of the myocardial region is computed from the distance between these contours in a predetermined part (A) of the image (images). The location of the myocardial region outside the preset region is derived on the basis of this distance.

Claims

1. A method of determining a position of the myocardium of the heart from a magnetic resonance (MR) image or a series of MR images of the heart of a patient, comprising the steps of:

first determining from the image or images a left ventricle contour and a right ventricle contour of the heart;

second determining a thickness measure of the myocardium based on a detected distance between said contours in a predetermined region in which both contours of the left and right ventricles extend such that outside said region the position of the myocardium is bounded by said left ventricle contour and an outer contour that extends outside said left ventricle contour at a distance that is equal to the thickness measure of the myocardium.

2. A method as set forth in claim 1, wherein the step of second determining includes that the thickness measure of the myocardium is determined by selection of the largest distance, or the mean distance, between said left ventricle contour and said right ventricle contour in the predetermined region.

3. A method as set forth in claim 1, wherein the step of second determining includes that the predetermined region in which said left ventricle and right ventricle contours extend is bounded by two tangent lines disposed at distinct locations which partly coincide with, or are tangent to, said right ventricle contour and which intersect one another at a center of gravity of the left ventricle.

4. A method as set forth in claim 3, wherein the step of second determining includes that at least two lines of intersection that segment the myocardium are formed by the tangent lines that bound the region in which the left ventricle contour and the right ventricle contour extend at some distance from one another.

5. A magnetic resonance (MR) method for determining perfusion parameters of the heart of a patient while administering a contrast liquid, comprising the steps of:

first calculating a position of the myocardium of the heart from a magnetic resonance (MR) image or a series of MR images of the heart of a patient, which step of calculating further comprises the steps of;

first determining from the image or images a left ventricle contour and a right ventricle contour of the heart,

second determining a thickness measure of the myocardium based on a detected distance between said contours in a predetermined region in which both contours of the left and right ventricles extend such that outside the region the position of the myocardium is bound by the left ventricle contour and an outer contour that extends outside the left ventricle contour at a distance that is equal to the thickness measure of the myocardium;

segmenting the myocardium;

second calculating a time intensity curve that represents the variation in time of the concentration of the contrast liquid in the myocardium for at least one segment; and

deriving the perfusion parameters from the time intensity curve.

6. A method as set forth in claim 5, wherein the step of second calculating includes determining that the at least one segment whose time intensity curve is determined is a predetermined position in the myocardium.

7. A method as set forth in claim 5, wherein the step of segmenting includes generating lines of intersection through the left ventricle contour and the outer contour that originates from the center of gravity of the left ventricle.

8. A method as set forth in claim 5, wherein the step of second calculating includes further determining a time window bound by a starting time T_B and a finishing time T_E for the analysis of the variation of the time intensity curve, that for the left ventricle an instant T_LV is determined at which a maximum is reached in the variation of a time intensity curve of the left ventricle, that the starting time T_B is determined to be the instant at which the time intensity curve of the left ventricle reaches a predetermined fraction of said maximum, where T_B is smaller than T_LV, and that the finishing time T_E is derived from the variation of the time intensity curve of the myocardium by adding a predetermined time delay W to the instant T_MYO at which this curve reaches a maximum value.