Iontophoretic fluid delivery device

• US 7,047,069 B2
• Filed: 02/04/2002
• Issued: 05/16/2006
• Est. Priority Date: 02/04/2002
• Status: Active Grant

• Current Assignee: ActivaTek Inc. (North Coast Medical, Inc.)
• Original Assignee: Ceramatec, Inc.
• Inventors: Joshi, Ashok V.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Maiorino, Roz
• Application Number:
  US10/067,623
• Publication Number:
  US 20030149393A1
• Time in Patent Office: 1,562 Days
• Field of Search: 604/20, 604/501, 424442-449
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body

Abstract

A low cost, accurate, single use, disposable, iontophoretic fluid delivery device having cationic and anionic chambers separated by container structure and arranged to promote a flow of treatment ions into a body. The device desirably uses rugged minibatteries safely to provide increased electromotive force to the ion transfer process compared to galvanic cells having electrolyte matched to a human body'"'"'s electrolyte. Minibatteries may be located in one or both cationic and anionic chambers, and/or attached to structure of a container outside the chambers. A shunt resistance may be arranged in a parallel circuit to the body to control delivery of a beneficial agent in any amount between 1 mAmp-min to 500 mAmp-min, or more. Substrates, located in the chambers and adapted to hold electrolyte or treatment drugs, may be electrically conductive to resist polarization of the chemicals near a conducting terminal. Cationic and anionic chambers may be made having different sizes and/or shapes to facilitate placement of treatment drugs into the correct chamber.

Claims

1. An A disposable iontophoretic fluid delivery device comprising:

a cationic chamber defining a volume in which to hold a cationic substance, a wall of said chamber having a first passageway permitting migration therethrough by ions;

an anionic chamber defining a volume in which to hold an anionic substance, a wall of said anionic chamber having a second passageway permitting migration therethrough by ions, said first and second passageways being oriented and arranged on a surface of a container to enable creation of an ion conducting path, through a cooperating body, of an electrical circuit between said cationic and anionic chambers;

a first electromotive cell comprising a mini battery configured to produce a single, approximately square-wave current discharge over the first electromotive cell'"'"'s working life and comprising first and second poles of opposite electrical sign, said first electromotive cell being disposed in an electron conducting path configured to complete said electrical circuit; and

a shunt resistance disposed in parallel with an ion conducting path between said cationic and anionic chambers, said shunt resistance selected to control the delivery of fluid from the iontophoretic fluid delivery device;

wherein a quantity of energy from said mini battery is substantially exhausted after delivery of a treatment dose.

2. The disposable iontophoretic fluid delivery device of claim 1, wherein said first electromotive cell comprising the mini battery is constructed to operate with a metal-anode based electro-chemical reaction, wherein said metal is selected from the group consisting of lithium, zinc, magnesium, and aluminum.

3. The disposable iontophoretic fluid delivery device of claim 1, wherein said container comprises an adhesive patch.

4. The disposable iontophoretic device of claim 3, a value of said shunt resistance being selected to determine a quantity of energy from said mini battery for direction through said ion conducting path for delivery of a beneficial agent.

5. The disposable iontophoretic device of claim 4, wherein said shunt resistance has a value between about 1 Ohm and about 10,000 Ohms.