Resorbable structure for treating and healing of tissue defects
First Claim
1. A porous polymeric device, said device being implantable to treat tissue or defects therein;
- said device comprising a polymer matrix, pores, and at least one modeling agent;
wherein said device comprises a plurality of internal surfaces that define a plurality of said pores, wherein at least said pores are arranged substantially homogeneously throughout said device, wherein said pores are of irregular shapes due to interactions with said at least one pore modeling agent during processing, and further wherein substantially each of said internal surfaces has expanded at least partially around an external surface of at least one modeling agent, thereby imparting an inward-directed textured or roughened face to said internal surfaces, and wherein said modeling agent is at least partially exposed to said pores, and further wherein said modeling agent comprises chitosan and sodium hyaluronate that can chemically react with each other upon exposure of said pores to a fluid.
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Accused Products
Abstract
Devices and processes (e.g., improved Plasticized Melt Flow processes (PMF) or improved Phase Separation Polymer Concentration (PSPC), etc.) used to make resorbable and non-resorbable structures for treating and/or healing of tissue defects are disclosed. Among the advantages of using these improved processes are the preservation of molecular weight and the broadening of the processing conditions for temperature sensitive polymers and therapies This reduction in processing temperature, pressure and time can help to preserve the molecular weight and/or integrity of the final product or any additive incorporated therein. The present invention relates to an improved porous implant wherein the pores of the implant present a second modeling material on their surfaces. This second material provides a textured or roughened face to the internal surfaces of pores. Additionally, this second material can be incorporated in sufficient quantity to, among other things, create a microporous network connecting interior closed cell pores with the exterior of the device.
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Citations
10 Claims
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1. A porous polymeric device, said device being implantable to treat tissue or defects therein;
- said device comprising a polymer matrix, pores, and at least one modeling agent;
wherein said device comprises a plurality of internal surfaces that define a plurality of said pores, wherein at least said pores are arranged substantially homogeneously throughout said device, wherein said pores are of irregular shapes due to interactions with said at least one pore modeling agent during processing, and further wherein substantially each of said internal surfaces has expanded at least partially around an external surface of at least one modeling agent, thereby imparting an inward-directed textured or roughened face to said internal surfaces, and wherein said modeling agent is at least partially exposed to said pores, and further wherein said modeling agent comprises chitosan and sodium hyaluronate that can chemically react with each other upon exposure of said pores to a fluid. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10)
- said device comprising a polymer matrix, pores, and at least one modeling agent;
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3. The device of claim 3, wherein, but for said modeling agent, pores interior to an external surface of said device would be closed off from said external surface.
Specification