Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor

• US 7,049,425 B2
• Filed: 03/30/2001
• Issued: 05/23/2006
• Est. Priority Date: 03/31/2000
• Status: Expired due to Fees

• Current Assignee: Wake Forest University
• Original Assignee: Wake Forest University
• Inventors: Mach, Robert H., Wang, Li-Ming, Shelness, Gregory, Childers, Steven, Wheeler, Kenneth T.
• Primary Examiner(s): Murphy, Joseph
• Assistant Examiner(s): BASI, NIRMAL SINGH
• Application Number:
  US09/823,069
• Publication Number:
  US 20020061847A1
• Time in Patent Office: 1,880 Days
• Field of Search: 435/7.1, 435/69.1, 435/252.3, 435/325, 530/300, 530/350, 536/23.1, 536/24.31
• US Class Current: 536/23.5
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748

Abstract

A new variant of the sigma-1 (σ₁)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—_1β (σ_1β) finds particular use in the non-invasive diagnosis of cancer and more particularly in the diagnosis of proliferative cancer cells.

Claims

1. An isolated polynucleotide which encodes for the amino acid sequence of SEQ ID NO:

2.

3. An expression vector comprising a polynucleotide according to claim 1.

4. A An isolated cell comprising an expression vector according to claim 3.

5. An isolated cell comprising an expression vector according to claim 4 and capable of expressing σ

_1β

.

6. A An isolated transformed host cell comprising the polynucleotide of claim 1.

2. An isolated polynucleotide comprising the nucleotide sequence of SEQ ID NO:

1.