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Method of tissue modulation for noninvasive measurement of an analyte

  • US 7,050,842 B2
  • Filed: 07/11/2001
  • Issued: 05/23/2006
  • Est. Priority Date: 07/11/2000
  • Status: Expired due to Fees
First Claim
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1. A method of noninvasive spectroscopic measurement of an analyte in a subject comprising:

  • (a) irradiating tissue of the subject through a nail with electromagnetic radiation having an excitation wavelength while the tissue is in a blood-replete state;

    (b) collecting the Raman spectra emitted by the tissue in the blood-replete state;

    (c) applying a tissue modulation device having an orifice to the nail of the subject so as to achieve a blood-depleted state within the tissue;

    (d) irradiating the tissue through the nail with electromagnetic radiation having an excitation wavelength while the tissue is in the blood-depleted state;

    (e) collecting the Raman spectra emitted by the tissue in the blood-depleted state; and

    (f) analyzing the collected Raman spectra to determine a concentration of analyte present in the tissue, wherein the analyzing comprises determining the difference between the Raman spectra collected in the blood-replete and blood-depleted states.

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