High throughput screening of crystallization of materials
First Claim
1. A method for crystallizing a target material comprising:
- providing a microfabricated elastomeric block having a chamber therein;
introducing into the chamber a solution of the target material; and
introducing a crystallization agent into the solution in the chamber by entrapping a volume of crystallizing agent proximate to the chamber and then opening an elastomer valve positioned between the chamber and the crystallization agent to allow diffusion of crystallization agent into the chamber.
3 Assignments
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Accused Products
Abstract
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
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Citations
9 Claims
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1. A method for crystallizing a target material comprising:
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providing a microfabricated elastomeric block having a chamber therein;
introducing into the chamber a solution of the target material; and
introducing a crystallization agent into the solution in the chamber by entrapping a volume of crystallizing agent proximate to the chamber and then opening an elastomer valve positioned between the chamber and the crystallization agent to allow diffusion of crystallization agent into the chamber. - View Dependent Claims (2, 3)
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4. A method for crystallizing a target material comprising:
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providing a microfabricated elastomeric structure having a chamber therein;
introducing into the chamber a solution of the target material;
introducing a volume of a crystallization agent into the solution in the chamber, wherein the crystallizing agent is introduced into the chamber by entrapping a volume of crystallizing agent proximate to the chamber, and then opening an elastomer valve positioned between the chamber and the crystallization agent to allow diffusion of crystallization agent into the chamber; and
,obtaining an image of the elastomeric structure.
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5. A method for crystallizing a target material comprising:
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providing a microfabricated elastomeric structure having a chamber therein;
introducing into the chamber a solution of the target material; and
introducing a volume of a crystallization agent into the solution in the chamber, wherein the crystallizing agent is introduced into the chamber by entrapping a volume of crystallizing agent proximate to the chamber, and then opening an elastomer valve positioned between the chamber and the crystallization agent to allow diffusion of crystallization agent into the chamber; and
,inspecting the chamber to reveal the presence of a crystal. - View Dependent Claims (6, 7, 8, 9)
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Specification