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Targeted controlled delivery compositions activated by changes in pH or salt concentration

  • US 7,053,034 B2
  • Filed: 04/10/2002
  • Issued: 05/30/2006
  • Est. Priority Date: 04/10/2002
  • Status: Active Grant
First Claim
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1. A controlled release composition comprising:

  • a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent and a cationic surface active agent, said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns.

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