Targeted controlled delivery compositions activated by changes in pH or salt concentration
First Claim
1. A controlled release composition comprising:
- a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent and a cationic surface active agent, said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns.
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Abstract
The present invention relates to a novel controlled release carrier system for pH or salt triggered release and targeted delivery of fragrances and other active ingredients onto fabric, hair, skin, and other biological surfaces and which provides prolonged release of fragrances and other active ingredients over an extended period of time, or yields a high impact fragrance “burst” upon treating the target surface with heat (blow drying the hair, ironing the fabric). The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising the fragrance and other active ingredients that are encapsulated in a pH or salt sensitive micro-spheres. Also described are processes for preparing such compositions and processes for using same. Furthermore, certain components of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in fabric, hair, and skin care preparations. The invention further pertains to consumer and diversified products comprising the controlled release system of the present invention.
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Citations
29 Claims
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1. A controlled release composition comprising:
a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent and a cationic surface active agent, said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A controlled release composition comprising:
a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent, and a cationic surface active agent said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material, and a second active agent encapsulated in said pH sensitive or salt sensitive matrix material wherein said pH sensitive or salt sensitive matrix material releases said second active agent upon contact with a solution having a predetermined pH in the range of about 3 to about 12 wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns. - View Dependent Claims (22, 23)
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24. A controlled release composition comprising:
a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent, said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material, a cationic charge booster within said solid nano-sphere wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns. - View Dependent Claims (25)
- 26. A fragrance carrier system comprising a composition comprising a plurality of solid nano-spheres including a fragrance and a cationic conditioning agent are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material wherein each of said nano-spheres has an average size of about 0.05 to about 2 microns and said micro-sphere has a size of from about 2 microns to about 50 microns.
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29. A method for forming a controlled release composition, said composition comprising:
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a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent, comprising a fragrance said plurality of nano-spheres are formed of a hydrophobic material, said plurality of nano-spheres being encapsulated within a pH sensitive or salt sensitive micro-sphere, said pH sensitive or salt sensitive micro-sphere is formed of a pH sensitive or salt sensitive matrix material, a second active agent encapsulated in said pH sensitive or salt sensitive matrix material wherein said pH sensitive or salt sensitive matrix material releases said second active agent upon contact with a solution having a pH in the range of about 3 to about 12wherein said nano-spheres are formed of a hydrophobic material comprising the steps of; heating said hydrophobic material to a temperature above the melting point to form a hot melt; dissolving or dispersing said first active agent into the melt; dissolving or dispersing said second active agent, and said pH or salt sensitive matrix material, in an aqueous phase and heating it to above the melting temperature of said hydrophobic material; mixing the hot melt with said aqueous phase to form a dispersion; high shear homogenization of the dispersion at a temperature above the melting temperature until a homogeneous fine dispersion is formed; cooling the dispersion to ambient temperature to form an emulsified mixed suspension; and spray drying the emulsified mixed suspension to form a dry powder composition.
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Specification