Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor
First Claim
Patent Images
1. A DNA expression vector comprising a nucleic acid sequence encoding a human IgG1 heavy chain constant region sequence of SEQ ID NO:
- 10, and a nucleic acid sequence encoding a humanized 1D9 heavy chain variable region.
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Abstract
Featured are DNA molecules, expression vectors, and host cells useful for creation of immunoglobulins, as well as novel immunoglobulin molecules termed monobodies. Additionally provided are methods of production of immunoglobulins, including monobodies, as well as methods of using the disclosed immunoglobulin and monobody constructs, expression vectors and host cells containing DNA encoding molecules for production of immunoglobulin and monobody proteins.
76 Citations
37 Claims
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1. A DNA expression vector comprising a nucleic acid sequence encoding a human IgG1 heavy chain constant region sequence of SEQ ID NO:
- 10, and a nucleic acid sequence encoding a humanized 1D9 heavy chain variable region.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 32, 33, 34, 35, 36, 37)
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22. A DNA expression vector comprising a nucleic acid sequence encoding the heavy chain constant region sequence of SEQ ID NO:
- 10, a nucleic acid sequence encoding a humanized 1D9 heavy chain variable region, a nucleic acid encoding the light chain constant region sequence of SEQ ID NO;
12, and a nucleic acid sequence encoding a humanized 1D9 light chain variable region. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31)
- 10, a nucleic acid sequence encoding a humanized 1D9 heavy chain variable region, a nucleic acid encoding the light chain constant region sequence of SEQ ID NO;
Specification