Pulsewidth electrical stimulation

• US 7,054,686 B2
• Filed: 09/13/2002
• Issued: 05/30/2006
• Est. Priority Date: 08/30/2001
• Status: Expired due to Fees

• Current Assignee: Biophan Technologies Incorporated
• Original Assignee: Biophan Technologies Incorporated
• Inventors: MacDonald, Stuart G.
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): Oropeza, Frances P.
• Application Number:
  US10/243,015
• Publication Number:
  US 20030055457A1
• Time in Patent Office: 1,355 Days
• Field of Search: 600/373, 600/377, 600/378, 600/393, 600/509, 600/544, 607/4, 607/5, 607/9, 607/45, 607/46, 607/117, 607/118, 607/119, 607/123
• US Class Current: 607/9
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

A process for stimulating tissue such as cardiac tissue, nerve tissue, and brain tissue. In one step of the process, there is delivered an electrical stimulating signal to the tissue that contains from about 10 to about 1,000 individual pulses. Each individual pulse has a duration of from about one microsecond to about 100 microseconds and is discontinuous, with a spacing between adjacent pulses of at least from about 1 microsecond to about 100 microseconds. The individual pulses have a voltage of from about 10 millivolts to about 100 volts.

Claims

1. A process for stimulating tissue selected from the group consisting of cardiac tissue, nerve tissue, brain tissue, and combinations thereof, comprising:

delivering an electrical stimulating signal to the tissue, the electrical stimulating signal having about 10 to about 1,000 individual pulses, the individual pulses forming a first set of pulses and a second set of pulses, each individual pulse having a duration of from about one microsecond to about 100 microseconds, the individual pulses being discontinuous, with a spacing between adjacent pulses of at least from about 1 microsecond to about 100 microseconds, and the individual pulses each having a voltage of from about 10 millivolts to about 100 volts, the first set of pulses having a first voltage of about 10 millivolts to about 100 volts, the second set of pulses having a second voltage of about 10 millivolts to about 100 volts, the first voltage being different from the second voltage.

2. The process recited in claim 1, wherein the tissue is heart tissue and the electrical stimulating signal is delivered by a cardiac assist device.

3. The process as claim 1, wherein the tissue is brain tissue and the electrical stimulating signal is delivered by a deep brain stimulator.

4. The process as recited in claim 1, wherein the tissue is vagas nerve tissue.

5. The process as recited in claim 1, wherein the electrical stimulating signal is provided a by a stimulating device comprising a first sensing electrode and a second sensing electrode.

6. The process as recited in claim 1, wherein the electrical stimulating signal is provided a by a stimulating device comprising a first stimulating electrode and second stimulating electrode.

7. The process as recited in claim 1, wherein the individual pulses are delivered to the organ or nerve within a period of less than about 10 milliseconds, each of the pulses having a voltage of from about 2 to about 20 volts direct current, the time between the delivery of a first pulse and a second and further pulses is at least about 1 microsecond, individual pulses being delivered to the organ or nerve at a frequency of from about 2 kilohertz to about 5 megahertz, and individual pulses each having a duration of from about 0.1 microseconds to about 500 milliseconds.

8. The process as recited in claim 7, wherein the spacing between the individual pulses is from about 1 microsecond to about 100 microseconds.

9. The process as recited in claim 1, wherein the electrical signal is delivered by a device implanted within a biological organism.

16. The process as recited in claim 1, wherein the individual pulses are delivered to the organ or nerve within a period of less than about 10 milliseconds, each of the pulses having a voltage of from about 2 to about 20 volts direct current, the time between the delivery of a first pulse and a second and further pulses is at least about 1 microsecond, individual pulses being delivered to the organ or nerve at a frequency of from about 2 kilohertz to about 5 megahertz, and individual pulses each having a duration of from about 0.1 microseconds to about 500 milliseconds.

17. The process as recited in claim 7, wherein the spacing between the individual pulses is from about 1 microsecond to about 100 microseconds.

18. The process as recited in claim 1, wherein the electrical signal is delivered by a device implanted within a biological organism.

10. A process for stimulating tissue selected from the group consisting of cardiac tissue, nerve tissue, brain tissue, and combinations thereof, comprising:

delivering an electrical stimulating signal to the tissue, the electrical stimulating signal having about 10 to about 1,000 individual pulses, the individual pulses forming a first set of pulses and a second set of pulses, each individual pulse having a duration of from about one microsecond to about 100 microseconds, the individual pulses being discontinuous, with a spacing between adjacent pulses of at least from about 1 microsecond to about 100 microseconds, and the individual pulses each having a voltage of from about 10 millivolts to about 100 volts, the first set of pulses having a first duration of about one microsecond to about 100 microseconds, the second set of pulses having a second duration of about one microsecond to about 100 microseconds, the first duration being different from the second duration.

11. The process recited in claim 10, wherein the tissue is heart tissue and the electrical stimulating signal is delivered by a cardiac assist device.

12. The process as claim 10, wherein the tissue is brain tissue and the electrical stimulating signal is delivered by a deep brain stimulator.

13. The process as recited in claim 10, wherein the tissue is vagas nerve tissue.

14. The process as recited in claim 10, wherein the electrical stimulating signal is provided a by a stimulating device comprising a first sensing electrode and a second sensing electrode.

15. The process as recited in claim 10, wherein the electrical stimulating signal is provided a by a stimulating device comprising a first stimulating electrode and second stimulating electrode.