Early stage multipotential stem cells in colonies of bone marrow stromal cells
First Claim
1. A population of human marrow stromal cells enriched for small and rapidly self-renewing stem (RS) cells, said population comprising about 95% RS cells, wherein said RS cells are about seven microns in diameter, comprise granular and agranular cells, and do not express STRO-1, PDGF-R, EGF-R, CD10 and CD147.
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Abstract
Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS cells had a greater potential for multipotential differentiation than samples enriched for mMSCs. Also, RS cells have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. The results suggest that it will be important to distinguish the two major sub-populations of MSCs in defining their biology and their potentials for cell and gene therapy.
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Citations
9 Claims
- 1. A population of human marrow stromal cells enriched for small and rapidly self-renewing stem (RS) cells, said population comprising about 95% RS cells, wherein said RS cells are about seven microns in diameter, comprise granular and agranular cells, and do not express STRO-1, PDGF-R, EGF-R, CD10 and CD147.
Specification