Lactam glycogen phosphorylase inhibitors and method of use
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Abstract
A compound of formula I
wherein
- W is a bicyclic hetroaryl of the structure
-
- X is —O—, —S—, —SO2—, —CHR5—, —CHR5O—, —CHR5S—, —CHR5SO2—, —CHR5CO— or —CH2CHR5—;
- Y is a bond or —CHR6—;
- Z is an aryl or heteroaryl group of the following structure:
-
- A is —CH— or —N—;
- B is —O— or —S—; and
- R1, R2, R3, R4, R5, R6, R7 and R8 are as described herein.
Further provided is a method for treating diabetes and related diseases employing a glycogen phosphorylase inhibiting amount of the above compound, either alone or in combination with another therapeutic agent.
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Citations
10 Claims
- 1. A compound of formula I
- 2. A pharmaceutical composition that inhibits the enzyme glycogen phosphorylase comprising a compound of formula I
Specification