Optical interrogation system and method for using same

• US 7,057,720 B2
• Filed: 06/24/2003
• Issued: 06/06/2006
• Est. Priority Date: 06/24/2003
• Status: Expired due to Fees

• Current Assignee: Corning Incorporated
• Original Assignee: Corning Incorporated
• Inventors: Fontaine, Norman H., Caracci, Stephen J.
• Primary Examiner(s): Toatley, Jr., Gregory J.
• Assistant Examiner(s): GEISEL, KARA E
• Application Number:
  US10/602,304
• Publication Number:
  US 20040263841A1
• Time in Patent Office: 1,078 Days
• Field of Search: 356/300, 356/328, 356/334, 359/641
• US Class Current: 356/300
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 2201/04 Batch operation; multisample devices
• CPC Class Codes: G01N 2201/10 Scanning
• CPC Class Codes: G02B 27/1086 operating by diffraction only

Abstract

An optical interrogation system and method are described herein that are capable of generating light beams that have desired optical properties which are directed towards a specimen array. In one embodiment, the optical interrogation system includes a light source, a diffractive element and a collimating optic (e.g., simple lens(es), f-θ lens(es), segmented mirror, fiber array). The light source emits a light beam to the diffractive optic which receives the light beam and outputs an array of light beams to the collimating optic. The collimating optic receives and conditions the light beams emitted from the diffractive optic and then outputs the conditioned light beams which have desired optical properties towards a specimen array. Several other embodiments of the optical interrogation system are also described herein.

Claims

1. An optical interrogation system comprising:

a light source for outputting a light beams;

a diffractive optic for receiving the light beam and outputting an array of light beams;

a collimating optic for receiving and conditioning the array of light beams and outputting the conditioned array of light beams which have desired optical properties towards a specimen array;

wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic; and

wherein said fiber array includes a plurality of fibers each of which has one end arranged on a circumference of a sphere and another end connected to a grid.

2. The optical interrogation system of claim 1, further comprising a detector for receiving an array of light beams reflected from the specimen array.

3. The optical interrogation system of claim 1, further comprising a beam reconditioning optic located between said light source and said diffractive optic and used for controlling the numerical aperture, spot size, and angle of incidence of each light beam emitted from said collimating optic that impinges a plane of the specimen array.

4. The optical interrogation system of claim 1, further comprising a wavelength tunable filter located between said light source and said diffractive optic and used to adjust each light beam emitted from said collimating optic to enable wavelength interrogation of the specimen array.

5. The optical interrogation system of claim 1 is used to interrogate grating or non-grating based sensors in a specimen array.

6. The optical interrogation system of claim 1 is used in one of the following applications including Infrared and Ultra-violet Absorption Spectroscopy, Fourier Transform Infrared Absorption (FTIR) Spectroscopy, Raman Spectroscopy, Reflection Spectroscopy, Fluorescence Spectroscopy, Flourescence Lifetime Spectroscopy or Surface Plasmon Resonance Spectroscopy.

7. The optical interrogation system of claim 1 has optical frequencies that span across the entire usable electromagnetic frequency spectrum.

8. An optical interrogation system comprising:

a light source for outputting a light beam;

a diffractive optic for receiving the light beam and outputting an array of light beams;

a collimating optic for receiving and conditioning the array of light beams and outputting the conditioned array of light beams which have desired optical properties towards a specimen array; and

a mask located between said collimating optic and said specimen array and used to block predetermined conditioned light beams from reaching selected specimens in the specimen array.

9. The optical interrogation system of claim 8, wherein said mask is an electronically controlled liquid crystal mask.

10. The optical interrogation system of claim 8, wherein said collimating optic is a simple lens, array of simple lenses, f-θ

lens, parabolic mirror, segmented mirror, or a refracting lens made from a set of precisely placed and angled refracting wedges.

11. The optical interrogation system of claim 8, wherein said collimating optic is a segmented mirror and each segment of said segmented mirror reflects one of the light beam is emitted from said diffractive optic so that the reflected light beam is equidistant from neighboring reflected light beams when impinging a plane of the specimen array.

12. The optical interrogation system of claim 8, wherein said collimating optic is a lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

13. The optical interrogation system of claim 8, wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic.

14. The optical interrogation system of claim 8, wherein said collimating optic is a combined fiber array and lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

15. An optical interrogation system comprising:

a light source for outputting a light beam;

a diffractive optic for receiving the light beam and outputting an array of light beams;

a collimating optic for receiving and conditioning the array of light beams and outputting the conditioned array of light beams which have desired optical properties towards a specimen array; and

a mask located between a detector and said specimen array and used to block predetermined light beams reflected from selected specimens in the specimen array.

16. The optical interrogation system of claim 15, wherein said mask is an electronically controlled liquid crystal mask.

17. The optical interrogation system of claim 15, wherein said collimating optic is a simple lens, array of simple lenses, f-θ

lens, parabolic mirror, segmented mirror, or a refracting lens made from a set of precisely placed and angled refracting wedges.

18. The optical interrogation system of claim 15, wherein said collimating optic is a segmented mirror and each segment of said segmented mirror reflects one of the light beams emitted from said diffractive optic so that the reflected light beam is equidistant from neighboring reflected light beams when impinging a plane of the specimen array.

19. The optical interrogation system of claim 15, wherein said collimating optic is a lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

20. The optical interrogation system of claim 15, wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic.

21. The optical interrogation system of claim 15, wherein said collimating optic is a combined fiber array and lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

23. The optical interrogation system of claim 15, wherein said swept angle detection system includes:

a rotating mirror for reflecting an array of light beams reflected from the specimen array;

an aperture plate having one or more holes through which passes selected ones of the light beams reflected from the rotating mirror;

an array of photodetectors for receiving the light beams that passed through the aperture plate; and

a data acquisition system for analyzing data received from said array of photodetectors.

22. An optical interrogation system comprising:

a light source for outputting a light beam;

a diffractive optic for receiving the light beam and outputting an array of light beams;

a collimating optic for receiving and conditioning the array of light beams and outputting the conditioned array of light beams which have desired optical properties towards a specimen array; and

a swept angle detection system for receiving an array of light beams reflected from the specimen array.

24. An optical interrogation system comprising:

a light source for outputting a light beam;

a diffractive optic for receiving the light beam and outputting an array of light beams;

a collimating optic for receiving and conditioning the array of light beams and outputting the conditioned array of light beams which have desired optical properties towards a specimen array; and

a swept angle launch system including a rotatable beam deflector located between said light source and said diffractive optic to control the angle of incidence of the light beam directed into said diffractive optic.

25. A method for interrogating one or more specimens in a specimen array, said method comprising the steps of:

using a light source to generate a light beam;

using a diffractive optic to receive the light beam and output an array of light beams;

using a collimating optic to receive and condition the array of light beams and then output the conditioned array of light beams which have desired optical properties towards a specimen array;

wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic; and

wherein said fiber array includes a plurality of fibers each of which has one end arranged on a circumference of a sphere and another end connected to a grid.

26. The method of claim 25, further comprising the step of using a detector to receive an array of light beams reflected from the specimen array.

27. The method of claim 25, further comprising the step of using a beam reconditioning optic located between said light source and said diffractive optic to control the numerical aperture, spot size, and angle of incidence of each light beam emitted from said collimating optic that impinges a plane of the specimen array.

28. The method of claim 25, further comprising the step of using a wavelength tunable filter located between said light source and said diffractive optic to adjust each light beam emitted from said collimating optic to enable wavelength interrogation of the specimen array.

29. A method for interrogating one or more specimens in a specimen array, said method comprising the steps of:

using a light source to generate a light beam;

using a diffractive optic to receive the light beam and output an array of light beams; and

using a collimating optic to receive and condition the array of light beams and then output the conditioned array of light beams which have desired optical properties towards a specimen array; and

using a mask located between said collimating optic and said specimen array to block predetermined conditioned light beams from reaching selected specimens in the specimen array.

30. The method of claim 29, wherein said mask is an electronically controlled liquid crystal mask.

31. The method of claim 29, wherein said collimating optic is a simple lens, array of simple lenses, f-θ

lens, parabolic mirror, segmented mirror, or a refracting lens made from a set of precisely placed and angled refracting wedges.

32. The method of claim 29, wherein said collimating optic is a segmented mirror and each segment of said segmented mirror reflects one of the light beams emitted from said diffractive optic so that the reflected light beam is equidistant from neighboring reflected light beams when impinging a plane of the specimen array.

33. The method of claim 29, wherein said collimating optic is a lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

34. The method of claim 29, wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic.

35. The method of claim 29, wherein said collimating optic is a combined fiber array and lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

36. A method for interrogating one or more specimens in a specimen array, said method comprising the steps of:

using a light source to generate a light beam;

using a diffractive optic to receive the light beam and output an array of light beams; and

using a collimating optic to receive and condition the array of light beams and then output the conditioned array of light beams which have desired optical properties towards a specimen array; and

using a mask located between a detector and said specimen array to block predetermined light beams reflected from selected specimens in the specimen array.

37. The method of claim 36, wherein said mask is an electronically controlled liquid crystal mask.

38. The method of claim 36, wherein said collimating optic is a simple lens, array of simple lenses, f-θ

lens, parabolic mirror, segmented mirror, or a refracting lens made from a set of precisely placed and angled refracting wedges.

39. The method of claim 36, wherein said collimating optic is a segmented mirror and each segment of said segmented mirror reflects one of the light beams emitted from said diffractive optic so that the reflected light beam is equidistant from neighboring reflected light beams when impinging a plane of the specimen array.

40. The method of claim 36, wherein said collimating optic is a lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

41. The method of claim 36, wherein said collimating optic is a fiber array that re-conditions the optical character of each light beam emitted from said diffractive optic.

42. The method of claim 36, wherein said collimating optic is a combined fiber array and lenslet array that re-conditions the optical character of each light beam emitted from said diffractive optic.

43. A method for interrogating one or more specimens in a specimen array, said method comprising the steps of:

using a light source to generate a light beam;

using a diffractive optic to receive the light beam and output an array of light beams;

using a collimating optic to receive and condition the array of light beams and then output the conditioned array of light beams which have desired optical properties towards a specimen array; and

using a swept angle detection system to receive an array of light beams reflected from the specimen array.

44. The method of claim 43, wherein said swept angle detection system includes:

a rotating mirror for reflecting an array of light beams reflected from the specimen array;

an aperture plate having one or more holes through which passes selected ones of the light beams reflected from the rotating mirror;

an array of photodetectors for receiving the light beams that passed through the aperture plate; and

a data acquisition system for analyzing data received from said array of photodetectors.

45. A method for interrogating one or more specimens in a specimen array, said method comprising the steps of:

using a light source to generate a light beam;

using a diffractive optic to receive the light beam and output an array of light beams;

using a collimating optic to receive and condition the array of light beams and then output the conditioned array of light beams which have desired optical properties towards a specimen array; and

using a swept angle launch system including a rotatable or acousto-optical beam deflector located between said light source and said diffractive optic to control the angle of incidence of the light beam directed into said diffractive optic.