Particulate info to field units

• US 7,057,724 B1
• Filed: 03/20/2003
• Issued: 06/06/2006
• Est. Priority Date: 03/21/2002
• Status: Expired due to Fees

• Current Assignee: Pointsource Technologies, LLC
• Original Assignee: Institute of Critical Care Medicine
• Inventors: Quist, Gregory, Mead, Donald
• Primary Examiner(s): Nguyen, Tu T.
• Application Number:
  US10/393,459
• Time in Patent Office: 1,174 Days
• Field of Search: 356335-344, 4352871-2878, 435/6, 435/7.1, 422/55, 422/58, 422/67
• US Class Current: 356/343
• CPC Class Codes: G01N 15/1459 the analysis being performed on a sample stream
• CPC Class Codes: G01N 2021/4711 Multiangle measurement
• CPC Class Codes: G01N 21/47 Scattering, i.e. diffuse reflection G01N21/25, G01N21/41 take precedence G01N21/55 takes precedence

Abstract

An improvement in a system that includes a group of field units (10, 10A) that each identifies unknown microscopic particles by use of a computer that compares an unknown particle interrogation pattern to the interrogation patterns of a set of known species of particles, which facilitates upgrading of the group of field units. Each field unit is connected by a communication link (84) to a central station (80). The central station can send interrogation patterns of a new species of particle to the field unit computers, which store them in a known-species-particle memory (34) that holds patterns of previously known species of particles. The field unit stores the patterns of unidentified particles in a memory (90) and notifies the central station when it has detected an invasion of a new species.

Claims

1. In a system for identifying unknown microscopic particles in a fluid, which includes a plurality of field units at different locations, wherein each field unit has an interrogation system that produces raw data interrogation patterns that are each unique to an unknown particle that is interrogated, and each field unit has a field unit computer that attempts to identify those particles as one of a plurality of known species of particles by comparing a raw data interrogation pattern produced during interrogation of the unknown particles with stored interrogation patterns of known species of particles, the improvement wherein:

said field unit computers each has a known-species-patterns memory that stores raw data interrogation patterns produced by each of said known species; and

including

a central station that is connected through a communication link to said field unit computers, and that transmits signals representing a group of new raw data interrogation patterns for a known new species of microscopic particles, said field unit computer being constructed to receive said signals representing new interrogation patterns for new species and to thereafter add said interrogation patterns to its known-species-patterns memory.

2. The system described in claim 1 wherein:

each of a plurality of said field units has an unidentified-species memory that stores the raw data interrogation patterns of at least some of the unknown particles that are not identified as one of the plurality of known species by the field unit computer;

each of said field unit computers is constructed to analyze the patterns of multiple unidentified particles to determine whether or not the patterns of a group of said multiple unidentified particles are similar enough to each other to indicate the presence of multiple particles of a new species of particle in the fluid.

3. The system described in claim 1 wherein:

said interrogation system comprises a light source that produces a beam of light that passes through said fluid, including a detect zone of limited length along said beam and in said fluid, and a plurality of photodetectors that each detects light scattered in each of a plurality of different directions from said detect zone, with outputs of said plurality of photodetectors comprising an unknown particle raw data interrogation pattern representing the unknown particle, the raw data interrogation patterns of multiple particles of the same known species being stored in said known-species memory, and said computer being constructed to compare the raw data interrogation pattern of said unknown particle to the interrogation patterns stored in said known-species-particle memory.

4. A system for identifying unknown microscopic particles in a fluid, which includes interrogating apparatus that directs a light beam through the fluid and a plurality of photodetectors that detect light scattered in different directions from a detect zone lying along the beam and in the fluid, with the outputs of said plurality of photodetectors constituting a raw data interrogation pattern, and where the interrogating apparatus includes an in-field computer that compares the raw data interrogation pattern produced by an unknown particle with multiple interrogation patterns stored in a known-species-particle memory that contains known interrogation patterns representing particles that are microorganisms of known species that were interrogated in the same or similar interrogating apparatus, including:

a central station and a communication link between said central station and said interrogating apparatus, said central station constructed to send a group of new raw data interrogation patterns representing a new species of microorganism, to said in-field computer and said in-field computer being constructed to add said group of new raw data interrogation patterns to said known-species-particle memory.

5. The system described in claim 4 wherein:

said in-field computer has an unidentified-species memory, and said in-field computer is constructed to store the raw data interrogation patterns of at least those particles which are not found to be a member of said known species in said unidentified-species-memory;

said in-field computer is constructed to determine whether or not a group of said raw data interrogation patterns stored in said unidentified-species memory, and that represent at least a predetermined percent of raw data interrogation patterns stored in said unidentified-species memory, are sufficiently similar to indicate that they are likely to be all of the same species, and to notify said central station when said group that are likely all of the same species, are found.

6. A microscopic particle identification method for use with a system that identifies which, if any, of a predetermined group of known species of microscopic particles whose interrogation patterns are stored in a known-species-particle memory of a computer, that an unknown particle belongs to, by interrogating the unknown particle to produce a raw data interrogation pattern that is unique to the unknown particle, and comparing the raw data interrogation pattern of the unknown particle to interrogation patterns of said predetermined group of known species of particles, including:

transmitting new raw data interrogation patterns of a new species of microscopic particle over a transmission link from a central station to said in-field computer and storing said new interrogation patterns in said known-species-particle memory, and thereafter comparing raw data interrogation patterns of unknown particles to interrogation patterns of a new group of known particles wherein said new group includes the interrogation patterns of said new species of microscopic particle.

7. The method described in claim 6 including:

storing the raw data interrogation patterns of unknown particles and analyzing them to determine whether or not the patterns of a group of said unknown particles are similar enough to indicate the presence of a significant percent of particles that are all of a new species of particles.