Multi-balloon catheter with hydrogel coating
First Claim
1. A balloon catheter for occluding two ends of a portion of a blood vessel and treating the occluded portion of the blood vessel comprising:
- a first balloon and a second balloon, each having an exterior surface and a catheter segment connectively placed therebetween; and
a coating comprising a hydrogel polymer applied to the exterior surfaces of each of the balloons,wherein said catheter segment is capable of delivering a biologically active agent to the occluded portion of the blood vessel and wherein said balloons are capable of being inflated and deflated within the blood vessel, and when the balloons are inflated, form a substantially fluid-tight, closed space between the first and second balloons.
3 Assignments
0 Petitions
Accused Products
Abstract
In one aspect of the invention a multi-balloon catheter, such as a double-balloon catheter, with coating comprising a hydrogel polymer on the exterior surface of the occlusion balloons is provided. The balloons may be inflated inside the lumen to occlude a plaque-affected segment of the lumen thereby forming a lumen space between the balloons, wherein this plaque-affected lumen segment may be treated with a biologically active agent. The presence of the coating can reduce de-nuding of healthy endothelial lumen tissue after contact with the inflated balloons during the occlusion. In another aspect of the invention, a method is provided for using a multi-balloon catheter having a coating comprising a hydrogel polymer for treating a plaque-affected lumen segment, the method reducing the subsequent de-nuding or injury to healthy endothelial tissue that is contacted by the balloon during occlusion.
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Citations
34 Claims
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1. A balloon catheter for occluding two ends of a portion of a blood vessel and treating the occluded portion of the blood vessel comprising:
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a first balloon and a second balloon, each having an exterior surface and a catheter segment connectively placed therebetween; and a coating comprising a hydrogel polymer applied to the exterior surfaces of each of the balloons, wherein said catheter segment is capable of delivering a biologically active agent to the occluded portion of the blood vessel and wherein said balloons are capable of being inflated and deflated within the blood vessel, and when the balloons are inflated, form a substantially fluid-tight, closed space between the first and second balloons. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A balloon catheter for occluding two ends of a portion of a blood vessel and treating the occluded portion of the blood vessel comprising:
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a first balloon and a second balloon, each having an exterior surface and a catheter segment connectively placed therebetween; and a coating comprising a hydrogel polymer applied to the exterior surfaces of each of the balloons, wherein said catheter segment is capable of delivering a biologically active agent to the occluded portion of the blood vessel and wherein said balloons are capable of being inflated and deflated within the blood vessel, and when both balloons are inflated, form a substantially fluid-tight, closed space between the first and second balloon, and wherein said coating is substantially free of any biologically active agent. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for treating a body lumen using a double-balloon catheter that maintains the integrity of the endothelial cells of the inner wall of the body lumen, the method comprising:
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(a) inserting a catheter having at least two balloons into the body lumen, wherein the balloons are coated with a coating comprising a hydrogel polymer; (b) inflating both balloons to contact the endothelial cells of the inner wall of the body lumen; (c) forming a substantially closed space between the balloons within the body lumen; and (d) providing a biologically active agent into the closed space. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A method for treating a body lumen using a double-balloon catheter that maintains the integrity of the endothelial cells of the inner wall of the body lumen, the method comprising:
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(a) inserting a catheter having at least two balloons into the body lumen, wherein the balloons are coated with a coating comprising a hydrogel polymer, and wherein said coating is substantially free of any biologically active agent; (b) inflating both balloons to contact the endothelial cells of the inner wall of the body lumen; (c) forming a substantially closed space between the balloons within the body lumen; and (d) providing a biologically active agent into the closed space. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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Specification