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Methods of treating diabetes mellitus

  • US 7,060,675 B2
  • Filed: 02/13/2002
  • Issued: 06/13/2006
  • Est. Priority Date: 02/15/2001
  • Status: Expired due to Term
First Claim
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1. A method of treating diabetes mellitus in a human patient in need of such treatment, said method comprising:

  • orally administering to the human patient between about 0.05 and 10 mg per kilogram body weight of an insulin polypeptide-oligomer conjugate comprising the structure of Formula III;


    Insulin polypeptide-X(CH2)m(OC2H4)nOR 



    (III) 

    wherein;

    X is a moiety which forms an ester moiety, a thio-ester moiety, an ether moiety, a carbamate moiety, thio-carbamate moiety, a carbonate moiety, a thio-carbonate moiety, an amide moiety, a urea moiety, or a covalent bond;

    m is between 1 and 24;

    n is between 1 and 50; and

    R is an alkyl moiety, a sugar moiety, cholesterol, adamantane, an alcohol moiety, or a fatty acid moiety;

    to the human patient within one hour prior to ingestion of a meal or contemporaneously with ingestion of a meal by the human patient in order to treat diabetes mellitus in the human patient, wherein the effective amount of the conjugate of Formula III is administered so that it provides an insulin drug concentration in portal vein blood between about 10 and 1,000 U/ml within about 60 minutes of administration.

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