Pharmaceutical coating composition and method of use

• US 7,060,734 B1
• Filed: 11/22/2000
• Issued: 06/13/2006
• Est. Priority Date: 09/09/1997
• Status: Expired due to Fees

• Current Assignee: Encinal Pharmaceutical Investments, LLC
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Li, Shu, Yum, Si-Hong, Edgren, David E., Wong, Patrick S.-L., Dong, Liang-Chang, Bhatti, Gurdish
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US09/721,111
• Time in Patent Office: 2,029 Days
• Field of Search: 424/480, 424/463, 424/484, 424/488, 424/495, 514/975, 514/781, 514/772.7, 525/398, 525/403
• US Class Current: 514/781
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

Claims

1. A composition consisting essentially of:

a combination of ethylcellulose and amphiphilic triblock copolymer surfactant, wherein the amphiphilic triblock copolymer surfactant consists of a triblock copolymer of ethylene oxide-propylene oxide-ethylene oxide and the composition in dry coated form includes 40 wt % to 99.5 wt % ethyl cellulose and 0.5 wt % to 60 wt % of the amphiphilic triblock copolymer surfactant; and

a single organic solvent, wherein the ethyl cellulose and the amphipilic triblock polymer surfactant are each dissolved in the single organic solvent.

2. The composition according to claim 1, wherein the molecular weight of the amphiphilic triblock copolymer surfactant is 2,200 to 15,000.

3. The composition of claim 1, wherein the ethylene oxide-propylene oxide-ethylene oxide triblock copolymer comprises, on a molar basis, 3 to 20 moles of ethylene oxide.

4. The composition of claim 1, wherein the ethylene oxide-propylene oxide-ethylene oxide triblock copolymer comprises, on a molar basis, 45 to 80 moles of ethylene oxide.

5. The composition of claim 1, wherein the ethylene oxide-propylene oxide-ethelene oxide triblock copolymer comprises, on a molar basis, 50 to 110 moles of ethylene oxide.

6. The composition of claim 1, wherein the ethylene oxide-propylene oxide-ethelene oxide triblock copolymer comprises, on a molar basis, 70 to 130 moles of ethylene oxide.

7. The composition of claim 1, wherein the ethylene oxide-propylene oxide-ethelene oxide triblock copolymer comprises, on a molar basis, 110 to 170 moles of ethylene oxide.