Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
First Claim
1. A method of screening an array of samples comprising analyzing an array of samples with a system for detecting similarities among a plurality of samples, which comprisesa) a device for obtaining a spectrum for each sample;
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Abstract
Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.
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Citations
23 Claims
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1. A method of screening an array of samples comprising analyzing an array of samples with a system for detecting similarities among a plurality of samples, which comprises
a) a device for obtaining a spectrum for each sample; - and
b) a computer configured to analyze each of the spectra and to generate a plurality of bins, wherein each bin corresponds to samples sharing at least one spectral feature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification