Combination and method including a visual marker for determining compliance with a medication regimen
First Claim
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1. A method of monitoring the compliance of a patient in following a medication regimen, said method comprising the steps of:
- providing in combination an orally administrable composition, which is part of a medication regimen, and multiple markers present in said combination, one of said markers causing a contact coloration of at least a portion of a mucous membrane or buccal membrane of the oral and/or pharyngeal cavity of a patient following oral ingestion of said combination by said patient for a longer time than another of said markers, the half-life of at least one marker being comparable to the half-life of said composition;
visually observing the oral and/or pharyngeal cavity of said patient;
determining the presence or absence of said contact coloration for determining whether said patient has ingested said combination in compliance with the medication regimen; and
determining the presence or absence of contact coloration caused by the multiple markers to determine a time frame in which the combination was ingested.
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Abstract
A method and combination including a visual marker for monitoring a patient to determine compliance with a medication regimen. An orally administrable medication composition is provided in combination with a visual marker. When the combination is orally ingested, the marker causes a coloration or discoloration of the oral and/or pharyngeal cavity of a subject. By visually observing the oral and/or pharyngeal cavity of the subject, one can determine whether medication has been ingested based upon the presence or absence of the coloration/discoloration.
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Citations
24 Claims
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1. A method of monitoring the compliance of a patient in following a medication regimen, said method comprising the steps of:
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providing in combination an orally administrable composition, which is part of a medication regimen, and multiple markers present in said combination, one of said markers causing a contact coloration of at least a portion of a mucous membrane or buccal membrane of the oral and/or pharyngeal cavity of a patient following oral ingestion of said combination by said patient for a longer time than another of said markers, the half-life of at least one marker being comparable to the half-life of said composition; visually observing the oral and/or pharyngeal cavity of said patient; determining the presence or absence of said contact coloration for determining whether said patient has ingested said combination in compliance with the medication regimen; and determining the presence or absence of contact coloration caused by the multiple markers to determine a time frame in which the combination was ingested. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. In combination:
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an orally administrable composition; and multiple markers, wherein one of said multiple markers causes a contact coloration of at least a portion of a mucous membrane or buccal membrane of the oral and/or pharyngeal cavity of a patient for a longer time than another of the markers following ingestion of said combination by said patient, the half-life of said marker being comparable to the half-life of said composition; said contact coloration of the oral and/or pharyngeal cavity being visually observable for determining whether said patient has ingested said combination in compliance with a medication regimen and for determining a time frame in which the combination was ingested. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification