Cross chamber interval correlation

• US 7,062,316 B2
• Filed: 01/21/2003
• Issued: 06/13/2006
• Est. Priority Date: 04/01/1999
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Sweeney, Robert J., Hsu, William
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): Oropeza, Frances P.
• Application Number:
  US10/347,725
• Publication Number:
  US 20030109792A1
• Time in Patent Office: 1,239 Days
• Field of Search: 600/372, 600/373, 600/374, 600/508, 600/509, 600/515, 600/516, 600/518, 600/519, 600/521, 607/4, 607/5, 607/9, 607/14, 607/119
• US Class Current: 600/518
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.

Claims

1. A system for determining a direction of conduction of an arrhythmia episode between a first cardiac region and a second cardiac region, the system comprising:

a first electrode to sense a first signal indicative of first contractions in the first cardiac region;

a second electrode to sense a second signal indicative of second contractions in the second cardiac region;

a first contraction detector circuit, coupled to the first electrode, to detect the first contractions;

a second contraction detector circuit, coupled to the second electrode, to detect the second contractions;

a cardiac data analyzing circuit coupled to the first contraction detector circuit and the second contraction detector circuit, the cardiac data analyzing circuit adapted to;

determine first cycle lengths each being a time interval between two successively sensed first contractions;

determine second cycle lengths each being a time interval between two successively sensed second contractions; and

analyze the first and second contractions to determine an occurrence of an arrhythmia episode having a one-to-one association of the first contractions to the second contractions;

a cycle length pairing circuit coupled to the cardiac data analyzing circuit, the cycle length pairing circuit adapted to pair the first cycle lengths with the second cycle lengths in first and second directions during the arrhythmia episode having the one-to-one association of the first contractions to the second contractions, the first direction corresponding to a direction of conduction of the arrhythmia episode from the first cardiac region to the second cardiac region, the second direction corresponding to a direction of conduction of the arrhythmia episode from the second cardiac region to the first cardiac region; and

a processor coupled to the cycle length pairing circuit, the processor adapted to;

determine correlation coefficients each for the first cycle lengths paired with the second cycle lengths in one of the first and second directions; and

determine the direction of the conduction of the arrhythmia episode based on the correlation coefficients.

2. The system of claim 1, wherein the first electrode is an atrial electrode, and the second electrode is a ventricular electrode.

3. The system of claim 2, further comprising a pacing output circuit coupled to the atrial electrode.

4. The system of claim 2, further comprising a pacing output circuit coupled to the ventricular electrode.

5. The system of claim 1, wherein the cycle length pairing circuit is adapted to:

pair the first cycle lengths with the second cycle lengths in the first direction, where for each of the paired first and second cycle lengths, the first cycle lengths starts before the second cycle length starts; and

pair the first cycle lengths with the second cycle lengths in the second direction, where for each of the paired first and second cycle lengths, the first cycle lengths starts after the second cycle length starts.

6. The system of claim 5, wherein the processor is adapted to:

determine a first correlation coefficient for the first cycle lengths paired with the second cycle lengths in the first direction;

determine a second correlation coefficient for the first cycle lengths paired with the second cycle lengths in the second direction; and

determining the direction of the conduction of the arrhythmia episode based on the first and second correlation coefficients.

7. The system of claim 1, wherein the cycle length pairing circuit is adapted to:

pair the first cycle lengths with the second cycle lengths in the first direction, where for each of the paired first and second cycle lengths, the first cycle length ends before the second cycle length starts; and

pair the first cycle lengths with the second cycle lengths in the second direction, where for each of the paired first and second cycle lengths, the first cycle length starts after the second cycle length ends.

8. The system of claim 7, wherein the processor is adapted to:

determine a first correlation coefficient for the first cycle lengths paired with the second cycle lengths in the first direction;

determine a second correlation coefficient for the first cycle lengths paired with the second cycle lengths in the second direction; and

determine the direction of the conduction of the arrhythmia episode based on the first and second correlation coefficients.

9. A method for determining a direction of conduction of an arrhythmia episode between a first cardiac region and a second cardiac region, the method comprising:

sensing first contractions from the first cardiac region and second contractions from the second cardiac region;

determining first cycle lengths from the first contractions;

determining second cycle lengths from the second contractions;

analyzing the first and second contractions for an occurrence of an arrhythmia episode that has a one-to-one association of the first contractions to the second contractions;

analyzing correlations between the first cycle lengths and the second cycle lengths during the arrhythmia episode; and

determining the direction of the conduction of the arrhythmia episode based on the correlations.

10. The method of claim 9, wherein the first cardiac region comprises an atrial region, and the second cardiac region comprises a ventricular region.

11. The method of claim 10, further comprising delivering pacing pulses to the atrial region during the arrhythmia episode.

12. The method of claim 10, further comprising delivering pacing pulses to the ventricular region during the arrhythmia episode.

13. The method of claim 9, wherein analyzing the correlations between the first cycle lengths and the second cycle lengths during the arrhythmia episode comprising:

pairing the first cycle lengths with the second cycle lengths in a first direction, where for each of the paired first and second cycle lengths, the first cycle lengths starts before the second cycle length starts;

pairing the first cycle lengths with the second cycle lengths in a second direction, where for each of the paired first and second cycle lengths, the first cycle lengths starts after the second cycle length starts;

determining a first correlation coefficient for the first cycle lengths paired with the second cycle lengths in the first direction; and

determining a second correlation coefficient for the first cycle lengths paired with the second cycle lengths in the second direction.

14. The method of claim 13, wherein determining the direction of the conduction of the arrhythmia episode based on the correlations comprises determining the direction of the conduction of the arrhythmia episode based on the first and second correlation coefficients.

15. The method of claim 14, wherein determining the direction of the conduction of the arrhythmia episode comprises determining that the arrhythmia episode is conducted from the first cardiac region to the second cardiac region when the first correlation coefficient is greater than the second correlation coefficient.

16. The method of claim 14, wherein determining the direction of the conduction of the arrhythmia episode comprises determining that the arrhythmia episode is conducted from the second cardiac region to the first cardiac region when the second correlation coefficient is greater than the first correlation coefficient.

17. The method of claim 14, comprising determining the first correlation coefficient and the second correlation coefficient each from a predetermined sample size of between 10 to 1000 paired first cycle lengths and second cycle lengths.

18. The method of claim 14, including using a Fisher Z transformation to determine whether the first correlation coefficient and the second correlation coefficient are statistically different.

19. The method of claim 9, wherein analyzing the correlations between the first cycle lengths and the second cycle lengths during the arrhythmia episode comprising:

pairing the first cycle lengths with the second cycle lengths in a first direction, where for each of the paired first and second cycle lengths, the first cycle length ends before the second cycle length starts;

pairing the first cycle lengths with the second cycle lengths in a second direction, where for each of the paired first and second cycle lengths, the first cycle length starts after the second cycle length ends;

determining a first correlation coefficient the first cycle lengths paired with the second cycle lengths in the first direction; and

determining a second correlation coefficient the first cycle lengths paired with the second cycle lengths in the second direction.

20. The method of claim 19, wherein determining the direction of the conduction of the arrhythmia episode based on the correlations comprises determining the direction of the conduction of the arrhythmia episode based on the first and second correlation coefficients.

21. The method of claim 20, wherein determining the direction of the conduction of the arrhythmia episode comprises determining that the arrhythmia episode is conducted from the first cardiac region to the second cardiac region when the first correlation coefficient is greater than the second correlation coefficient.

22. The method of claim 20, wherein determining the direction of the conduction of the arrhythmia episode comprises determining that the arrhythmia episode is conducted from the second cardiac region to the first cardiac region when the second correlation coefficient is greater than the first correlation coefficient.

23. The method of claim 20, comprising determining the first correlation coefficient and the second correlation coefficient each from a predetermined sample size of between 10 to 1000 paired first cycle lengths and second cycle lengths.

24. The method of claim 20, including using a Fisher Z transformation to determine whether the first correlation coefficient and the second correlation coefficient are statistically different.

25. A method, comprising:

sensing atrial contractions and ventricular contractions;

determining atrial cycle lengths each being a time interval between a sensed first atrial contraction and a successively sensed second atrial contraction;

determining ventricular cycle lengths each being a time interval between a sensed first ventricular contraction and a successively sensed second ventricular contraction;

analyzing the atrial contractions and ventricular contractions for an occurrence of a tachycardia episode having an one-to-one association of atrial contractions to ventricular contractions;

determining atrial timing difference values each between a first atrial cycle length and a succeeding second atrial cycle length during the tachycardia episode;

determining ventricular timing difference values each between a first ventricular cycle length and a succeeding second ventricular cycle length during the tachycardia episode; and

analyzing correlations between the atrial timing difference and the ventricular timing difference during the tachycardia episode; and

classifying the tachycardia episode based on the correlations.

26. The method of claim 25, wherein analyzing the correlations comprises:

pairing the atrial timing difference values with the ventricular timing difference values in an antegrade direction, where for each of the paired atrial and ventricular time difference values, the first atrial cycle length starts before the first ventricular cycle length starts;

pairing the atrial timing difference values with the ventricular timing difference values in a retrograde direction, where for each of the paired atrial and ventricular time difference values, the first atrial cycle length starts after the first ventricular cycle length starts;

determining an antegrade correlation coefficient for the atrial timing difference values paired with the ventricular timing difference values in the antegrade direction; and

determining a retrograde correlation coefficient for the atrial timing difference values paired with the ventricular timing difference values in the retrograde direction, and wherein classifying the tachycardia episode comprises classifying the tachycardia episode based on the antegrade correlation coefficient and the retrograde correlation coefficient.

27. The method of claim 26, wherein classifying the tachycardia episode comprises classifying the tachycardia episode as occurring in the antegrade direction if the antegrade correlation coefficient is greater than the retrograde correlation coefficient.

28. The method of claim 26, wherein classifying the tachycardia episode comprises classifying the tachycardia episode as occurring in the retrograde direction if the retrograde correlation coefficient is greater than the antegrade correlation coefficient.

29. The method of claim 25, wherein analyzing the corrections comprises:

pairing the atrial timing difference values with the ventricular timing difference values in a super-antegrade direction, where for each of the paired atrial and ventricular time difference values, the first atrial cycle length ends before the first ventricular cycle length starts;

pairing the atrial timing difference values with the ventricular timing difference values in a super-retrograde direction, where for each of the paired atrial and ventricular time difference values, the first atrial cycle length starts after the first ventricular cycle length ends;

determining a super-antegrade correlation coefficient for the atrial timing difference values paired with the ventricular timing difference values in the antegrade direction;

determining a super-retrograde correlation coefficient for the atrial timing difference values paired with the ventricular timing difference values in the retrograde direction, and wherein classifying the tachycardia episode comprises classifying the tachycardia episode based on the super-antegrade correlation coefficient and the super-retrograde correlation coefficient.

30. The method of claim 29, wherein classifying the tachycardia episode comprises classifying the tachycardia episode as occurring in the antegrade direction if the super-antegrade correlation coefficient is greater than the super-retrograde correlation coefficient.

31. The method of claim 29, wherein classifying the tachycardia episode comprises classifying the tachycardia episode as occurring in the retrograde direction if the super-retrograde correlation coefficient is greater than the super-antegrade correlation coefficient.

32. A system, comprising:

means for determining atrial cycle lengths each being a time interval between two successively sensed atrial contractions and determining ventricular cycle lengths each being a time interval between two successively sensed ventricular contractions;

means for detecting an occurrence of a tachycardia episode having an one-to-one association of the atrial contractions to the ventricular contractions;

means for analyzing correlations between the atrial cycle lengths and the ventricular cycle lengths during the tachycardia episode, the means for analyzing the correlations including;

means for pairing the atrial cycle lengths with the ventricular cycle lengths in an antegrade direction and pairing the atrial cycle lengths with the ventricular cycle lengths in a retrograde direction; and

means for determining an antegrade correlation coefficient for the atrial cycle lengths paired with the ventricular cycle lengths in the antegrade direction and determining a retrograde correlation coefficient for the atrial cycle lengths paired with the ventricular cycle lengths in the retrograde direction.

33. The system of claim 32, further comprising means for classifying the tachycardia episode based on the antegrade correlation coefficient and the retrograde correlation coefficient.

34. The system of claim 33, further comprising means for delivering pacing pulses during the tachycardia episode.