Selective organ hypothermia method and apparatus

• US 7,063,718 B2
• Filed: 03/05/2003
• Issued: 06/20/2006
• Est. Priority Date: 01/23/1998
• Status: Expired due to Fees

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Dobak, John D. III
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US10/382,223
• Publication Number:
  US 20030144714A1
• Time in Patent Office: 1,203 Days
• Field of Search: 607/96, 607104-106, 607/113
• US Class Current: 607/105
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A compressed refrigerant is pumped through the catheter to an expansion element near the distal tip of the catheter, where the refrigerant vaporizes and expands to cool a flexible heat transfer element in the distal tip of the catheter. The heat transfer element cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.

Claims

1. A method for treating an effect of disruption of blood flow to an organ using hypothermia, comprising:

resuscitating the patient; and

inducing hypothermia in the patient, wherein hypothermia is induced by circulating a heat exchange fluid through a catheter, having a flexible heat transfer element disposed at a distal portion thereof, positioned in the patient'"'"'s central venous system,

wherein the flexible heat transfer element is flexible enough to navigate from a femoral insertion point to at least a common carotid artery.

2. A method for treating an effect of disruption of blood flow to an organ using hypothermia, comprising:

inducing hypothermia in the patient, wherein hypothermia is induced by circulating a heat exchange fluid through a flexible catheter, having a flexible heat transfer element disposed at a distal portion thereof, positioned in the patient'"'"'s central venous system,

wherein the flexible heat transfer element is flexible enough to navigate from a femoral insertion point to at least a common carotid artery.

3. A method for treating an effect of disruption of blood flow to an organ using hypothermia, comprising:

percutaneously inserting a flexible catheter into a patient'"'"'s central venous system; and

inducing hypothermia in the patient, wherein hypothermia is induced by circulating a heat exchange fluid through the flexible catheter, having a flexible heat transfer element disposed at a distal portion thereof, positioned in the patient'"'"'s central venous system,

wherein the flexible heat transfer element is flexible enough to navigate from a femoral insertion point to at least a common carotid artery.

4. A method for treating an effect of disruption of blood flow to the heart using hypothermia, comprising:

percutaneously inserting a flexible catheter into a patient'"'"'s central venous system;

inducing hypothermia in the patient, wherein hypothermia is induced by circulating a heat exchange fluid through the flexible catheter, having a flexible heat transfer element disposed at a distal portion thereof, positioned in the patient'"'"'s central venous system,

wherein the flexible heat transfer element is flexible enough to navigate from a femoral insertion point to at least a common carotid artery.

5. A method for treating an effect of disruption of blood flow to the brain using hypothermia, comprising:

percutaneously inserting a flexible catheter into a patient'"'"'s central venous system;

inducing hypothermia in the patient, wherein hypothermia is induced by circulating a heat exchange fluid through the flexible catheter, having a flexible heat transfer element disposed at a distal portion thereof, positioned in the patient'"'"'s central venous system,

wherein the flexible heat transfer element is flexible enough to navigate from a femoral insertion point to at least a common carotid artery.