Recloseable biosensor

• US 7,063,774 B2
• Filed: 10/28/2002
• Issued: 06/20/2006
• Est. Priority Date: 07/20/2000
• Status: Expired due to Fees

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Hill, Brian S., Bhullar, Raghbir Singh, Walling, Douglas Paul
• Primary Examiner(s): Olsen, Kaj K.
• Application Number:
  US10/281,717
• Publication Number:
  US 20030047451A1
• Time in Patent Office: 1,331 Days
• Field of Search: 204/403.01, 204/403.02, 204/403.04, 204/403.14
• US Class Current: 204/403.02
• CPC Class Codes: B01L 2200/082 Handling hazardous material
• CPC Class Codes: B01L 2300/043 Hinged closures
• CPC Class Codes: B01L 2300/046 Function or devices integrated in the closure
• CPC Class Codes: B01L 2300/047 Additional chamber, reservoir
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/105 using desiccants
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: G01N 33/52 Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements immunological elements G01N33/54386; involving labelled immunochemicals G01N33/58; for haemoglobin or occult blood G01N33/72

Abstract

A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.

Claims

1. A recloseable biosensor comprising:

a substrate formed to include a sample site,

a reagent positioned at the sample site,

a cover including first and second ends and a middle portion between the ends, the first end of the cover being coupled to the substrate and the middle portion extending over the sample site and being releasable and recloseable over the sample site, and

a biocide positioned between the cover and the substrate and being spaced-apart from the reagent.

2. The biosensor of claim 1, further comprising a desiccant spaced apart from the sample site.

3. The biosensor of claim 2, wherein the biocide is positioned on the cover.

4. The biosensor of claim 3, wherein the desiccant is positioned in or on the cover.

5. The biosensor of claim 2, further comprising a second substrate extending over the sample site, a third substrate positioned on the second substrate, and wherein the desiccant is positioned in or on the third substrate.

6. The biosensor of claim 5, wherein a channel has a sample port adjacent to an end of the substrate and the cover is formed to extend across the sample port when the cover is in a closed position.

7. The biosensor of claim 2, wherein the substrate includes a first surface facing the sample site and a second surface and the first end of the cover is coupled to the second surface of the substrate.

8. The biosensor of claim 1, wherein the substrate includes a first surface facing the sample site and a second surface and the first end of the cover is coupled to the second surface of the substrate.

9. The biosensor of claim 8, wherein the cover is formed to extend about an end of the substrate when the cover is in a closed position.

10. The biosensor of claim 1, wherein the first end of the cover is coupled to the substrate with an adhesive.

11. The biosensor of claim 10, wherein the middle portion is coupled to the substrate by a releasable, resealable adhesive.

12. The biosensor of claim 10, wherein the middle portion is further coupled to the substrate by a releasable adhesive positioned between the releasable, resealable adhesive and the first end of the cover.

13. The biosensor of claim 12 wherein the releasable adhesive extends about a perimeter of the cover.

14. A biosensor comprising:

a substrate formed to include a sample site,

a reagent positioned at the sample site,

a cover extending across the reagent,

a biocide positioned between the cover and the substrate and being spaced-apart from the reagent, and

a desiccant spaced apart from the reagent.

15. The biosensor of claim 14, wherein the biocide is positioned on the cover.

16. The biosensor of claim 15, wherein the desiccant is positioned in or on the cover.

17. The biosensor of claim 15, wherein the substrate includes a first surface facing the reagent and a second surface and the first end of the cover is coupled to the second surface of the substrate.

18. The biosensor of claim 14, wherein the substrate includes a first surface facing the reagent and a second surface and the first end of the cover is coupled to the second surface of the substrate.

19. The biosensor of claim 14, wherein the cover includes a fixed end permanently coupled to the substrate and an opposite free end.

20. The biosensor of claim 19, wherein the cover includes a middle portion between the fixed and free ends and the middle portion is coupled to the substrate by a releasable, resealable adhesive.

21. A recloseable biosensor comprising:

a substrate,

a reagent positioned on the substrate,

an openable and recloseable cover including a fixed end coupled to the substrate, an opposite free end, and a middle portion extending between the opposite ends across the reagent, said cover being operative to selectively block access to the reagent, and

a biocide positioned between the cover and the substrate spaced-apart from the reagent.

22. The biosensor of claim 21, wherein the middle portion is coupled to the substrate by a releasable, resealable adhesive.

23. The biosensor of claim 21, further comprising a desiccant positioned in or on the cover.

24. The biosensor of claim 21, further comprising a desiccant positioned between the cover and the substrate.