Delivery of erectile dysfunction drugs through an inhalation route
First Claim
1. A condensation aerosol for delivery of a drug selected from the group consisting of sildenafil, tadalafil and vardenafil,wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol,characterized by less than 10% drug degradation products by weight, andan MMAD of less than 5 microns.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a patient through an inhalation route. The method comprises: a) heating a thin film of an erectile dysfunction drug, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% erectile dysfunction drug degradation products. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route is provided which comprises: a) a thin film of an erectile dysfunction drug composition and b) a device for dispensing said thin film as a condensation aerosol.
-
Citations
30 Claims
-
1. A condensation aerosol for delivery of a drug selected from the group consisting of sildenafil, tadalafil and vardenafil,
wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol, characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
-
4. A method of producing a drug selected from the group consisting of sildenafil, tadalafil and vardenafil in an aerosol form comprising:
-
a. heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and MMAD of less than 5 microns. - View Dependent Claims (5, 6, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
-
25. A condensation aerosol for delivery of sildenafil, wherein the condensation aerosol is formed by heating a thin layer containing sildenafil, on a solid support, to produce a vapor of sildenafil, and condensing the vapor to form a condensation aerosol characterized by less than 5% sildenafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
26. A condensation aerosol for delivery of tadalafil, wherein the condensation aerosol is formed by heating a thin layer containing tadalafil, on a solid support, to produce a vapor of tadalafil, and condensing the vapor to form a condensation aerosol characterized by less than 5% tadalafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
27. A condensation aerosol for delivery of vardenafil, wherein the condensation aerosol is formed by heating a thin layer containing vardenafil, on a solid support, to produce a vapor of vardenafil, and condensing the vapor to form a condensation aerosol characterized by less than 5% vardenafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
28. A method of producing sildenafil in an aerosol form comprising:
-
a. heating a thin layer containing sildenafil, on a solid support, to produce a vapor of sildenafil, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% sildenafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
-
29. A method of producing tadalafil in an aerosol form comprising:
-
a. heating a thin layer containing tadalafil on a solid support, to produce a vapor of tadalafil, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% tadalafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
-
30. A method of producing vardenafil in an aerosol form comprising:
-
a. heating a thin layer containing vardenafil, on a solid support, to produce a vapor of vardenafil, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% vardenafil degradation products by weight, and an MMAD of about 0.2 to about 3 microns.
-
Specification