Bioavailable composition of natural and synthetic HCA

• US 7,063,861 B2
• Filed: 08/17/2001
• Issued: 06/20/2006
• Est. Priority Date: 08/17/2000
• Status: Expired due to Term

• Current Assignee: Sami Labs Limited
• Original Assignee: Sabinsa Corporation (Sami-Sabinsa Group Limited)
• Inventors: Hadmaev, Vladimir, Majeed, Muhammed
• Primary Examiner(s): Azpuru, Carlos A.
• Application Number:
  US09/926,746
• Publication Number:
  US 20020187943A1
• Time in Patent Office: 1,768 Days
• Field of Search: 424/400, 424/451, 424/464, 424/439
• US Class Current: 424/451
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/125 Camphor; Nuclear substituted derivatives thereof
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to a composition comprising hydroxycitric acid (HCA) in combination with either one or both of garcinol and anthocyanin, and its use as a weight-loss therapy in animal subjects, preferably humans. The therapeutic effects for the composition observed in murine and human studies include a reduction in total body weight and body mass index, a reduction in body fat, an increase in lean body mass and content of body water, and a reduction in perceived appetite level. Another composition for use in weight-loss therapy is also described relating to forskolin in combination with either one or both of garcinol and anthocyanin. The anti-oxidant properties of garcinol are described as being enhanced in the presence of HCA and anthocyanin, and the combination of HCA, garcinol and anthocyanin is also shown to exert greater citrate lyase inhibiting properties than either compound alone. Methods of obtaining HCA, garcinol or anthocyanin, or a composition containing all three compounds, are described.

Claims

1. A method for increasing fat catabolism in a subject in need of such effect comprising administering to said subject a fat catabolizing effective amount wherein the active ingredients in said fat catabolizing amount consists essentially of hydroxycitric acid and garcinol of hydroxycitric acid and garcinol.

2. The method of claim 1, wherein the fat catabolizing effective amount of hydroxycitric acid and garcinol further comprises anthocyanin.

3. The method of claim 1, wherein the hydroxycitric acid is extracted from fruits of Garcinia sp. with organic solvents.

4. The method of claim 1, wherein the garcinol is extracted from fruits of Garcinia sp. with organic solvents.

5. The method of claim 2, wherein the hydroxycitric acid (HCA), garcinol and anthocyanin are extracted from fruits of Garcinia sp. with organic solvents.

6. The method of claim 1, wherein the hydroxycitric acid is extracted from fruits of Garcinia sp. by CO₂ supereritical extraction.

7. The method of claim 1, wherein the garcinol is extracted from fruits of Garcinia sp. by CO₂ supercritical extraction.

8. The method of claim 2, wherein the hydroxycitric acid, garcinol and anthocyanin are extracted from fruits of Garcinia sp. by CO₂ supercritical extraction.

9. The method of claim 1, wherein the fat catabolizing effective amount of hydroxycitric acid and garcinol also increases lean body mass.

10. The method of claim 2, wherein the fat catabolizing effective amount of hydroxycitric acid, garcinol and anthocyanin also increases lean body mass.

11. The method of claim 1, wherein the fat catabolizing effective amount of hydroxycitric acid and garcinol also promotes weight loss.

12. The method of claim 2, wherein the fat catabolizing effective amount of hydroxycitric acid, garcinol and anthocyanin also promotes weight loss.

13. The method of claim 1, wherein the fat catabolizing effective amount of hydroxycitric acid is 500 mg.

14. The method of claim 1, wherein the fat catabolizing effective amount of garcinol is 25 mg.

15. The method of claim 2, wherein the fat catabolizing effective amounts of hydroxycitric acid, garcinol and anthocyanin are 500 mg, 25 mg, and 10 mg respectively.

16. The method of claim 1, wherein the percentage of garcinol in the fat catabolizing effective amount of hydroxycitric acid and garcinol ranges from 0.01% to 10% relative to hydroxycitric acid.

17. The method of claim 2, wherein the percentage of garcinol in the fat catabolizing effective amount of hydroxycitric acid, garcinol and anthocyanin ranges from 0.01% to 10% relative to hydroxycitric acid.