Stent coating

• US 7,063,884 B2
• Filed: 02/22/2005
• Issued: 06/20/2006
• Est. Priority Date: 02/26/2003
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Tang, Yiwen, Pacetti, Stephen D., Hossainy, Syed F. A., Tung, Andrew C.
• Primary Examiner(s): Chen, Vivian
• Application Number:
  US11/064,916
• Publication Number:
  US 20050186248A1
• Time in Patent Office: 483 Days
• Field of Search: None
• US Class Current: 428/212
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: Y10T 428/13 Hollow or container type article [e.g., tube, vase, etc.]
• CPC Class Codes: Y10T 428/24942 including components having same physical characteristic in differing degree

Abstract

A stent comprising a coating layer is disclosed. The coating layer has a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface of the coating layer has a higher content or concentration of the hydrophilic component than the hydrophobic component.

Claims

1. A stent comprising a coating layer, the coating layer having a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface of the coating layer has a higher content or concentration of the hydrophilic component than the hydrophobic component and wherein the hydrophilic component has a solubility parameter higher than about 8.5 (cal/cm³)^1/2.

2. The stent of claim 1, wherein the hydrophobic and hydrophilic components are blended in the coating layer.

3. The stent of claim 1, wherein the hydrophobic and hydrophilic components are bonded in the coating layer.

4. The stent of claim 1, wherein the hydrophobic and hydrophilic components are an interpenetrating polymer network.

5. The stent of claim 1, wherein the solubility parameter is higher than about 9.0 (cal/cm³)^1/2.

6. The stent of claim 1, wherein the solubility parameter is higher than about 9.5 (cal/cm³)^1/2.

7. The stent of claim 1, wherein the solubility parameter is higher than about 10.0 (cal/cm³)^1/2.

8. The stent of claim 1, wherein the solubility parameter is higher than about 10.5 (cal/cm³)^1/2.

9. The stent of claim 1, wherein the solubility parameter is higher than about 11.0 (cal/cm³)^1/2.

10. The stent of claim 1, wherein the solubility parameter is higher than about 11.5 (cal/cm³)^1/2.

11. The stent of claim 1, wherein the hydrophobic component has a solubility parameter less than about 11.5 (cal/cm³)^1/2.

12. The stent of claim 1, wherein the coating layer includes one or a combination of a primer layer, a reservoir layer including a drug and a topcoat layer.

13. The stent of claim 1, wherein the coating layer is the outermost layer of a coating construct.

14. The stent of claim 1, wherein the ratio of the hydrophilic component to the hydrophobic component is between about 1:

100 and about 1;

9.