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Transgenic mammals having human Ig loci including plural VHand VKregions and antibodies produced therefrom

  • US 7,064,244 B2
  • Filed: 02/19/2002
  • Issued: 06/20/2006
  • Est. Priority Date: 12/03/1996
  • Status: Expired due to Fees
First Claim
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1. A transgenic mouse whose genome comprises a fragment of human chromosome 14 from the five most proximal VH gene segments, continuing through the D segment genes, the J segment genes and the constant region genes through Cδ

  • of the human immunoglobulin heavy chain locus, wherein said fragment does not contain a Cγ

    gene, and wherein said fragment is operably linked to a human Cγ

    gene selected from the group consisting of;

    a human Cγ

    1 gene, a human Cγ

    3 gene, and a human Cγ

    4 genesaid transgenic mouse producing fully human antibodies having IgG1, IgG3, or IgG4 heavy chains, respectively, specific for a desired antigen when immunized with said desired antigen.

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