Method and apparatus for automatically programming CRT devices

• US 7,065,400 B2
• Filed: 02/14/2004
• Issued: 06/20/2006
• Est. Priority Date: 08/20/2003
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Schechter, Stuart O.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/779,162
• Publication Number:
  US 20050043895A1
• Time in Patent Office: 857 Days
• Field of Search: 607 4- 5, 607/30, 607/32, 607 17- 26
• US Class Current: 607/2
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

External or internal monitoring equipment is used to automatically determine optimal programming parameters for a CRT based on externally or internally derived measurements of cardiac performance, anisotropic myocardial deformation (AMD) or both. The ideal programming parameter, operational parameter, represents optimal interval timing between multiple electrodes within the CRT, and is generated by such a closed loop control system. The closed loop system may be semi-automatic and implement connectivity to external ultrasound equipment or externally derived measurements of transthoracic impedance. Preferably, the operational parameter is determined by a closed loop system using internally derived intracardiac and intrathoracic electrograms and impedance measurements that describe cardiac performance and electromechanical dysynchrony in real time. Such a CRT has a control system that automatically optimizes performance by a system of checks and balance.

Claims

1. An apparatus for programming an implantable medical device comprising:

a programmer that provides operational parameters to the implantable medical device;

an impedance measuring device that measures an intra-thoracic impedance between two spaced apart electrodes and determines a programming parameter for a patient'"'"'s heart based on said intra-thoracic impedance; and

a calculator receiving said programming parameter and generating said operational parameter for said programmer.

2. The apparatus of claim 1 wherein said programmer applies a plurality of stimulations to the patient'"'"'s heart and said calculator monitors the resulting programming parameter and selects the optimal programming parameter and the corresponding operational parameter.

3. The apparatus of claim 1 wherein said monitor is implemented in the implantable medical device.

4. The apparatus of claim 1 wherein said programming parameter is indicative of cardiac performance.

5. The apparatus of claim 1 wherein said programming parameter is determined from a plurality of functions, each function being associated with a myocardial region during a cardiac cycle.

6. An apparatus for programming an implantable medical device, comprising:

a programmer that provides operational parameters to the implantable medical device;

a monitor that measures myocardial strain of specific regions of a patient'"'"'s heart and determines a programming parameter for the patient'"'"'s heart based on the measured strain; and

a calculator receiving said programming parameter and generating said operational parameter for said programmer.

7. An apparatus for programming an implantable medical device, comprising:

a programmer that provides operational parameters to the implantable medical device;

a monitor that measures myocardial velocity from specific regions of a patient'"'"'s heart and determines a programming parameter for the patient'"'"'s heart based on said myocardial velocities; and

a calculator receiving said programming parameter and generating said operational parameter for said programmer.

8. The apparatus of claim 7 wherein said monitor is external.

9. The apparatus of claim 7 wherein said monitor is ultrasonic equipment.

10. The apparatus of claim 9 wherein said programming parameter is indicative of anisotropic myocardial deformation, (AMD).

11. An apparatus for programming implantable medical device comprising:

equipment that monitors several programming parameters;

a calculator that selects an optimal parameter from said programming parameter and generates an operational parameter for said implantable medical device based on said optimal parameter, wherein said programming parameters depend on one of strain or velocity.

12. The apparatus of claim 11 wherein said calculator generates said optimal parameter based on one of cardiac performance and/or anisotropic myocardial deformation, (AMD).

13. An apparatus for programming implantable medical device comprising:

equipment that monitors several programming parameters;

a calculator that selects an optimal parameter from said programming parameter and generates an operational parameter for said implantable medical device based on said optimal parameter, wherein said programming parameters are based on Doppler ultrasound quantification of velocity of multiple pre-selected myocardial regions during a cardiac cycle.

14. The apparatus of claim 13 wherein said equipment comprises ultrasonic equipment for measuring myocardial strain in specific areas of interest.

15. An implantable medical device comprising:

equipment that monitors a programming parameter; and

a calculator that selects an optimal value for said programming parameter and uses said optimal value to generate an operational parameter, said operational parameter defining the normal mode of operation of said implantable medical device, wherein said equipment monitors an anisotropic myocardial deformation parameter and a cardiac performance parameter and said calculator selects the optimal value on both said anisotropic myocardial deformation and cardiac performance parameters.

16. The implantable medical device of claim 15 wherein said calculator monitors the performance of the heart and under certain pre-determined sub-critical or critical conditions switches from an operational parameter based on anisotropic myocardial deformation to an operational parameter based on cardiac performance.