Transdermal transport device with suction

• US 7,066,922 B2
• Filed: 10/21/2002
• Issued: 06/27/2006
• Est. Priority Date: 10/26/2001
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Hansen, Peter, Hunter, Ian W., Angel, Aimee B.
• Primary Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US10/278,050
• Publication Number:
  US 20030139727A1
• Time in Patent Office: 1,345 Days
• Field of Search: 604 20- 22, 604/501, 604272-274, 604/149, 604/152, 604/153, 604/264, 604115-117, 604/35, 604/276, 604/500, 606/167, 606/170, 606/185, 128/898, 424/448, 424/449, 600/573, 600/576, 600/583
• US Class Current: 604/500
• CPC Class Codes: A61M 2005/1405 Patient controlled analgesia [PCA]
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/65 Impedance, e.g. conductivity, capacity
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/425 Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles. Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially aligned in a plane parallel to a surface of the biological body when the device is placed on the surface. The device also includes a vacuum generator which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.

Claims

1. A transdermal transport device, comprising:

a reservoir for holding a formulation of an active principle;

one or more needles, each needle having a bore through which the formulation is transported between the reservoir and a biological body, each needle having an end portion that is substantially aligned in a plane substantially parallel to a surface of the biological body when the device is placed on the surface and adapted to translate in a direction that is substantially parallel to the plane, the one or more needles being rotatable about an axis that is substantially perpendicular to the plane; and

a vacuum generator which creates a suction to draw a portion of the surface beyond the plane of the end portions to enable the end portions to penetrate the portion of the surface as the one or more needles are translated in a direction that is substantially parallel to the plane.

2. The transdermal transport device of claim 1 wherein the vacuum generator is used to secure the device to the surface of the body.

3. The transdermal transport device of claim 2 wherein the vacuum generator is turned off after the needles penetrate the skin.

4. The transdermal transport device of claim 3, wherein the device is attached to the surface of the body with the one or more needles.

5. The transdermal transport device of claim 1, wherein the one or more needles are adapted to provide an insertion angle between 0°

and 90°

.

6. The transdermal transport device of claim 1, further comprising a mechanical stop adapted to control the depth of insertion of the one or more needles.

7. The transdermal transport device of claim 6, wherein the mechanical stop comprises a hard stop set to a desired distance from the plane of the one or more needles.

8. A transdermal transport device, comprising:

a needle having a bore through which a substance is transported, the needle having an end portion that is at least partially positioned between a plane substantially parallel to a surface of the biological body and the surface when the device is placed on the surface and adapted to translate substantially along a path that is substantially between the plane and the surface, the end portion being rotatable about an axis that is substantially perpendicular to the plane; and

a vacuum generator to create a suction drawing a portion of the surface beyond the end portion, enabling the end portion to penetrate the portion of the surface as the needle is translated along the path.

9. The transdermal transport device of claim 8, wherein the drawn portion has an apex the plane being perpendicular to a central axis of the apex.

10. The transdermal transport device of claim 9, wherein the needle provides an attachment to the portion of the surface by inserting into the surface of the skin, the attachment persisting after the vacuum generator is turned off.

11. A method of transdermally transporting a substance across a surface of a biological body, comprising the steps of:

providing suction to a target area of the surface of the biological body;

drawing by suction at least a portion of the target area in a direction away from the surface;

rotating a needle about an axis that is substantially perpendicular to the surface of the biological body; and

penetrating laterally with the needle the drawn portion of the target area.

12. The method of claim 11, further comprising the step of detachably attaching the device to the biological body using the needle, detachment being possible once the needle is withdrawn from the target area.

13. The method of claim 12, wherein the step of drawing by suction at least a portion of the target area includes causing the target area to move through a passage.

14. The method of claim 12, wherein withdrawal of the needle from the target area, occurs while the passage remains relatively stationary with respect to the needle.

15. The method of claim 12, wherein the detachable attachment remains attached when subject to gravitational force.

16. The method of claim 12 wherein withdrawal of the needle from the portion of the target area is such that the needle moves through a passage through which the portion of the target area enters as it is drawn by suction.

17. A transdermal transport device for transporting a substance across a surface of a biological body comprising:

a vacuum adapted to draw a portion of the surface of the biological body beyond a plane parallel to the surface; and

one or more needles, each needle rotatable about an axis substantially normal to the surface and having an end portion configured to penetrate the drawn portion of the surface when the one or more needles are rotated about the axis.

18. The transdermal transport device of claim 17, wherein the one or more needles are adapted to provide an insertion angle between zero degree and 90 degrees.

19. The transdermal transport device of claim 17, wherein the device is attached to the surface of the biological body with the one or more needles.

20. The transdermal transport device of claim 17, further comprising a mechanical stop adapted to control the depth of insertion of the one or more needles.

21. A transdermal transport device for transporting a substance across a surface of a biological body comprising:

a vacuum adapted to draw at least one portion of the surface of the biological body beyond a plane parallel to the surface; and

a plurality of needles rotatable about an axis substantially normal to the surface, at least one of the plurality of needles having an end portion configured to penetrate the drawn portion of the surface when the one or more needles are rotated about the axis.

22. The transdennal transport device of claim 21, wherein the vacuum is adapted to draw a plurality of portions of the surface of the biological body beyond a plane parallel to the surface, each needle of plurality of needles being configured to penetrate a respective drawn portion.

23. The transdermal transport device of claim 22, wherein the plurality of needles forms an attachment of the device to the biological body.

24. The transdermal transport device of claim 23, wherein the device remains attached to the biological body when the vacuum is removed.

25. A method of transdermally transporting a substance across a surface of a biological body, comprising the steps of:

applying a vacuum to draw at least one portion of the surface of the biological body beyond a plane parallel to the surface;

rotating a plurality of needles about an axis substantially normal to the surface of the biological body; and

penetrating the at least one drawn portion of the surface with the rotated plurality of needles.

26. The method of claim 25, further comprising the step of removing the vacuum after the at least one drawn portion of the surface has been penetrated.

27. The method of claim 26, wherein the plurality of needles form an attachment securing the device to the surface of the biological body.

28. The method of claim 27, wherein each of the plurality of needles penetrates a respective drawn portion of the surface of the biological body.