Method of using metaloporphyrins for treatment of arteriosclerotic lesions
First Claim
1. A method of treating arteriosclerotic disease comprising administering a therapeutically effective dose of a cytotoxic compound comprising a porphyrin complexed with a radioactive metal to a mammal.
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Abstract
A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin element indicate sites of plaque buildup. The radioactive metal within the compound is cytotoxic to cells in and surrounding the plaque and may allow tomographic scanning of the plaque as well. The complexed compound can be introduced to the patient a desired number of times to provide the necessary radiation treatment and ongoing monitoring of plaque removal.
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Citations
15 Claims
- 1. A method of treating arteriosclerotic disease comprising administering a therapeutically effective dose of a cytotoxic compound comprising a porphyrin complexed with a radioactive metal to a mammal.
- 12. A radiopharmaceutical composition for the treatment of arteriosclerosis comprising a porphyrin complexed with a cytotoxic radiation-emitting metal selected from the group consisting of 67Cu, 64Cu, 131I, 90Y, 186Re, 211At, 212Bi and 125I.
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14. A method of treating arteriosclerotic disease comprising administering a therapeutically effective dose of a cytotoxic compound comprising a porphyrin complexed with a radioactive metal to a mammal, wherein said radioactive metal does not have gamma emissions as its primary mode of decay.
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15. A method of treating arteriosclerotic disease comprising administering a therapeutically effective dose of a cytotoxic compound comprising a porphyrin complexed with a radioactive metal to a mammal, wherein said radioactive metal is selected from the group consisting of an alpha emitter, a beta emitter, and a combined beta and gamma emitter.
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