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Bioartificial device for the storage, cultivation and/or multiplication of cells

  • US 7,067,307 B2
  • Filed: 08/14/2003
  • Issued: 06/27/2006
  • Est. Priority Date: 02/14/2001
  • Status: Expired due to Fees
First Claim
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1. A bioartificial device, comprising:

  • a reactor vessel having a first end and a second opposite end, said reactor vessel being formed with a cell culture chamber, a first throughflow chamber for a nutrient medium separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, and a second throughflow chamber for a body substance separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, said first throughflow chamber for the nutrient medium being centrally disposed and being cylindrical with a wall including a semi-permeable membrane, and said second throughflow chamber being formed by a tube of semi-permeable material helically disposed in said cell culture chamber;

    said inlet ends of said first and second throughflow chambers being in fluid communication with feed connections disposed on said first end of said reactor vessel and said outlet ends of said first and second throughflow chambers being in fluid communication with discharge connections disposed on said first end of said reactor vessel with tubes guided through said reactor vessel and extending from said discharge connections to said outlet ends of said throughflow chambers.

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