Generation of combination of RF and axial DC electric fields in an RF-only multipole

• US 7,067,802 B1
• Filed: 02/11/2005
• Issued: 06/27/2006
• Est. Priority Date: 02/11/2005
• Status: Expired due to Fees

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Kovtoun, Viatcheslav V.
• Primary Examiner(s): Wells, Nikita
• Assistant Examiner(s): SMITH, JOHNNIE L
• Application Number:
  US11/056,547
• Time in Patent Office: 501 Days
• Field of Search: 250/292, 250/288, 250/281, 250/282, 250/287
• US Class Current: 250/282
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles

Abstract

An RF-only multipole includes a spiral resistive path formed around each multipole rod body. RF voltages are applied to the rod body and resistive path, and DC voltages are applied to the resistive path, to create a radially confining RF field and an axial DC field that assists in propelling ions through the multipole interior along the longitudinal axis thereof. In one implementation, the resistive path takes the form of a wire of resistive material, such as nichrome, which is laid down in the groove defined between threads formed on the rod body. The RF-only multipole of the invention avoids the need to use auxiliary rods or similar supplemental structures to generate the axial DC field.

Claims

1. An RF-only multipole, comprising:

at least four elongated rods held in spaced apart, mutually parallel relation, the rods defining an interior region through which ions are transmitted along the major axis of the multipole, each rod having a spiral resistive path disposed around a rod body and traversing at least a portion of the length of the rod;

a radio-frequency voltage source, coupled to each rod, for establishing an RF-only field that radially confines the ions; and

a direct current voltage source, for respectively applying first and second direct current voltages to first and second locations on the resistive path of each rod to generate an axial direct current field that propels the ions along the major axis.

2. The RF-only multipole of claim 1, wherein each rod comprises a threaded rod, and the resistive path comprises a wire disposed in the groove defined between adjacent threads of the threaded rod.

3. The RF-only multipole of claim 1, wherein each rod includes an electrically conductive rod body and an isolating layer interposed between the electrically conductive material and the resistive path.

4. The RF-only multipole of claim 3, wherein the rod body is formed of aluminum, and the isolating layer is an oxide layer formed by anodization.

5. The RF-only multipole of claim 3, wherein the RF-only field is established by applying a radio-frequency voltage to the rod body, the radio-frequency voltage being transferred to the wire through capacitive coupling across the isolator layer.

6. The RF-only multipole of claim 1, wherein application of the direct current potential across the resistive path causes substantial heating of the interior region of the multipole.

7. The RF-only multipole of claim 1, wherein the axial direct current field has a strength of at least 0.05 volts/centimeter.

8. The RF-only multipole of claim 1, wherein each rod is formed from an electrically insulative rod body, and the RF-only field is established by applying a radio-frequency voltage to a spiral conductive path disposed around the rod body.

19. The RF-only multipole of claim 1, wherein the DC potential within the interior region is substantially uniform in a radial plane orthogonal to the major axis.

20. The RF-only multipole of claim 1, wherein the DC voltages are combined with RF voltages prior to application to the multipole.

9. A mass spectrometer system, comprising:

an ion source for generating ions;

a mass analyzer for analyzing the mass-to-charge ratio of at least a portion of the ions; and

an RF-only ion guide for transferring ions along a segment of an ion path extending between the ion source and the mass analyzer, the ion guide comprising;

at least four elongated rods held in spaced apart, mutually parallel relation, the rods defining an interior region through which ions are transmitted along the major axis of the multipole, each rod having a spiral resistive path disposed around a rod body and traversing at least a portion of the length of the rod;

a radio-frequency voltage source, coupled to each rod, for establishing an RF-only field that radially confines the ions; and

a direct current voltage source, for respectively applying first and second direct current voltages to first and second locations on the resistive path of each rod to generate an axial direct current field that propels the ions along the major axis.

10. The mass spectrometer system of claim 9, wherein each rod comprises a threaded rod, and the resistive path comprises a wire disposed in the groove defined between adjacent threads of the threaded rod.

11. The mass spectrometer system of claim 9, wherein each rod includes an electrically conductive rod body and an isolating layer interposed between the electrically conductive rod body and the resistive path.

12. The mass spectrometer system of claim 11, wherein the the rod body is formed of aluminum, and the isolating layer is an oxide layer formed by anodization.

13. The mass spectrometer system of claim 11, wherein the RF-only field is established by applying a radio-frequency voltage to the rod body, the radio-frequency voltage being transferred through capacitive coupling across the isolator layer.

14. The mass spectrometer system of claim 9, wherein application of the direct current potential across the resistive path causes substantial heating of the interior region of the multipole.

15. The mass spectrometer system of claim 9, wherein the axial direct current field has a strength of at least 0.05 volts/centimeter.

16. The mass spectrometer system of claim 9, wherein each rod is formed from an electrically insulative rod body, and the RF-only field is established by applying a radio-frequency voltage to a spiral conductive path disposed around the rod body.

17. The mass spectrometer system of claim 9, wherein the ion source is a MALDI source having a laser for desorbing and ionizing a sample.

18. The mass spectrometer system of claim 17, wherein a beam path of the laser extends partially into the interior region of the ion guide.

21. The mass spectrometer system of claim 9, wherein the DC potential within the interior region is substantially uniform in a radial plane orthogonal to the major axis.

22. The mass spectrometer system of claim 9, wherein the DC voltages are combined with RF voltages prior to application to the multipole.