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Statistical method for assessing autonomic balance

  • US 7,069,070 B2
  • Filed: 05/12/2003
  • Issued: 06/27/2006
  • Est. Priority Date: 05/12/2003
  • Status: Expired due to Fees
First Claim
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1. A method for operating an implantable medical device in order to assess a subject'"'"'s autonomic balance, comprising:

  • sensing electrical activity in a ventricle and generating a ventricular sense signal when the sensed electrical activity exceeds a predetermined threshold;

    measuring time intervals between each pair of successive ventricular senses, referred to as RR intervals, over a predetermined long-term period, where N is the total number of RR interval measurements during the predetermined long-term period and the measured RR intervals RR1 through RRN are referred to as an RR time series;

    computing mean values Mx1 through MxL of successive x-second segments of the RR time series, where x is a predetermined number and L is the total number of such x-second segments in the RR time series, and computing a variance of the mean values Mx1 through MxL, referred to as [SDx]2;

    computing mean values My1 through MyK of successive y-second segments of the RR time series, where y is a predetermined number greater than x and K is the total number of such y-second segments in the RR time series, and computing a variance of the mean values My1 through MyK, referred to as [SDy]2;

    computing a mean value of squared successive differences between the RR intervals in the RR time series, referred to as [rMSSD]2; and

    ,estimating a ratio of the low frequency content in the RR time series between approximately 1/x Hz and 1/y Hz and higher frequency content in the RR time series, referred to as LF/HF, as;


    LF/HF=K([SDx]2

    [SD
    y]2)/[rMSSD]2wherein K is a defined constant and LF/HF is reflective of the subject'"'"'s autonomic balance.

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