Method and device for determining the segmental volume and electrical parallel conductance of a cardiac chamber or blood vessel

• US 7,069,072 B2
• Filed: 08/30/2001
• Issued: 06/27/2006
• Est. Priority Date: 09/07/2000
• Status: Expired due to Term

• Current Assignee: Cardio Dynamics
• Original Assignee: Jozef R.C. Jansen
• Inventors: Jansen, Jozef R. C., Schreuder, Johannes Jacobus
• Primary Examiner(s): NASSER, ROBERT L
• Application Number:
  US10/363,713
• Publication Number:
  US 20040024329A1
• Time in Patent Office: 1,762 Days
• Field of Search: None
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295

Abstract

The segment volume of a cardiac chamber or blood vessel of a patient is determined by injecting a first indicator in the blood stream of a patient, which influences the conductance of the blood. The electrical conductance in the cardiac chamber or blood vessel is measured. An injected quantity of indicator is determined and the development of the concentration of this indicator in the blood is measured wherein the cardiac output is calculated from the injected quantity of indicator and the development of the concentration in the blood. Subsequently, the segment volume and electrical parallel conductance of a cardiac chamber or blood vessel are calculated from the calculated cardiac output, the injected quantity of conductance indicator and the measured conductance.

Claims

1. A method for determining the segmental volume and the electrical parallel conductance of a cardiac chamber or a blood vessel of a patient, the method comprising:

injecting a conductance indicator, which influences electrical conductance of blood, into a bloodstream of a patient, wherein an injected quantity of the conductance indicator is determined;

measuring the electrical conductance in said cardiac chamber or blood vessel;

calculating a sum of segmental volume of said cardiac chamber or blood vessel and electrical parallel conductance from said measured electrical conductance;

measuring development of concentration of a concentration indicator in the bloodstream;

calculating the cardiac output from the injected quantity of concentration indicator and the development of the concentration thereof; and

calculating the segmental volume and the electrical parallel conductance of the cardiac chamber or the blood vessel from the calculated cardiac output, the injected quantity of conductance indicator and the measured electrical conductance.

2. The method according to claim 1, wherein the conductance indicator comprises the concentration indicator, and wherein measuring the development of the concentration comprises measuring the temperature or the color of the concentration indicator.

3. The method according to claim 1, and further comprising injecting the concentration indicator.

4. The method according to claim 1, and further comprising:

using the calculated parallel conductance a correction value; and

determining the segmental volume exclusively from the conductance signal using said correction value.

5. The method according to claim 1, and further comprising:

dividing a period of a heartbeat into equal time segments; and

monitoring continuously the segmental volume and the electric parallel conductance of the cardiac chamber or the blood vessel within the for multiple heartbeat.

6. An apparatus for determining a segmental volume of a cardiac chamber or a blood vessel of a patient, the apparatus comprising:

a processing unit having a control output for initiating injection of a conductance indicator into a bloodstream of the patient, which influences electrical conductance of blood;

a first detector configured to be placed in the cardiac chamber or blood vessel for measuring a conductance signal, which depends on the electrical conductance at the location of the first detector, wherein said processing unit is arranged for calculating the segmental volume of the cardiac chamber or the blood vessel from said conductance signal;

a second detector configured to be placed in the bloodstream for measuring an indicator signal depending on a concentration of a concentration indicator in the blood, wherein said processing unit is arranged for calculating the cardiac output from an injected quantity of the conductance indicator and the indicator signal, and calculating the segmental volume and electrical parallel conductance of the cardiac chamber or blood vessel from the calculated cardiac output, the injected quantity of conductance indicator and the conductance signal.

7. The apparatus according to claim 6, wherein the conductance indicator comprises the concentration indicator and wherein said second detector is adapted for measuring the concentration of said conductance indicator.

8. The apparatus according to claim 6, wherein the conductance indicator is different than the concentration indicator, and wherein said control output initiates the injection of the concentration indicator.

9. The apparatus according to claim 6, and further comprising at least one injector, wherein said control output controls said at least one injector device for injecting at least one of the conductance indicator and the concentration indicator.

10. The apparatus according to claim 6, wherein said processing unit uses the calculated parallel conductance as a correction value for determining the segmental volume exclusively from said conductance signal.

11. The apparatus according to claim 6, wherein said first and said second detectors are housed in a common catheter.

12. The apparatus according to claim 11, wherein said catheter also includes a lumen for injecting at least one of the conductance indicator and the concentration indicator.

13. A catheter for determining segmental volume and electrical parallel conductance of a cardiac chamber or a blood vessel of a patient, the catheter comprising:

a first detector configured for measuring a conductance signal depending on electrical conductance of blood;

a second detector configured for measuring an indicator signal depending on a concentration of a concentration indicator in the blood, wherein said first detector is positioned closer to a distal end than said second detector; and

a third detector corresponding to said first detector, which third detector is spaced from said distal end by such a distance so that the third detector is adapted to be positioned in an aorta when said first detector is positioned in a heart.

14. The catheter according to claim 13, wherein said second detector comprises a number of parallel electrodes, which are axially provided on the catheter.

15. The catheter according to claim 13, wherein the catheter includes a lumen comprising at least one outlet opening between said first detector and said distal end.

16. The catheter of claim 13, wherein the third detector is a conductance detector.