Medical device with array of electrode-containing reservoirs
First Claim
1. A device for use in medical diagnostics comprising:
- a substrate;
an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface;
a plurality of electrodes located at least partially inside the reservoirs;
a plurality of discrete reservoir caps covering the openings in the reservoirs; and
control circuitry for selectively disintegrating or permeabilizing the reservoir cap over the opening of at least one of the reservoirs.
1 Assignment
0 Petitions
Accused Products
Abstract
Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.
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Citations
29 Claims
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1. A device for use in medical diagnostics comprising:
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a substrate; an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface; a plurality of electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering the openings in the reservoirs; and control circuitry for selectively disintegrating or permeabilizing the reservoir cap over the opening of at least one of the reservoirs. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An implantable medical device for in vivo medical diagnostics comprising:
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a substrate; an array of reservoirs in the substrate, the reservoirs having interior sidewalls, a closed bottom surface, and an opening distal the bottom surface; a diagnostic reagent in the interior of the reservoirs; a plurality of electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the array of reservoirs; and control circuitry for selectively disintegrating the reservoir cap over the opening of at least one of the reservoirs, wherein the device is formed or coated with a biocompatible material and is suitable for implantation into a human or animal. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. A device for the controlled delivery of molecules comprising:
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a substrate; an array of reservoirs in the substrate; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate at least partially inside the reservoirs, wherein the one or more electrodes are not reservoir caps; and means for applying an electric current or potential across the one or more electrodes effective to activate release of the molecules from the reservoirs. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification