Delivery of diphenhydramine through an inhalation route
First Claim
1. A condensation aerosol for delivery of diphenhydraminewherein the condensation aerosol is formed by heating a thin layer containing diphenhydramine, on a solid support, to produce a vapor of diphenhydramine, and condensing the vapor to form a condensation aerosol,characterized by less than 10% diphenhydramine degradation products by weight, andan MMAD of less than 5 microns.
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Abstract
The present invention relates to the delivery of diphenhydramine through an inhalation route. In a composition aspect of the present invention, a composition of a diphenhydramine condensation aerosol is presented. In a method aspect of the present invention, diphenhydramine aerosol is formed by: a) heating a thin layer of diphenhydramine on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% degradation product and an aerosol having an MMAD less than 3 microns. In a kit aspect of the present invention, a kit for delivering a condensation aerosol is provided which comprises: a) a thin coating of diphenhydramine; and b) a device for dispensing the diphenhydramine as an aerosol.
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Citations
30 Claims
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1. A condensation aerosol for delivery of diphenhydramine
wherein the condensation aerosol is formed by heating a thin layer containing diphenhydramine, on a solid support, to produce a vapor of diphenhydramine, and condensing the vapor to form a condensation aerosol, characterized by less than 10% diphenhydramine degradation products by weight, and an MMAD of less than 5 microns.
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5. A method of producing diphenhydramine in an aerosol form comprising:
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a. heating a thin layer containing diphenhydramine, on a solid support, to produce a vapor of diphenhydramine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (6, 7, 8, 18, 19, 20, 21, 22, 23)
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9. A kit for delivering a diphenhydramine condensation aerosol comprising:
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a. a thin layer containing diphenhydramine, on a solid support, and b. a device for providing the condensation aerosol, wherein the condensation aerosol is formed by heating the thin layer to produce a vapor of diphenhydramine, and condensing the vapor to form a condensation aerosol characterized by less than 10% diphenhydramine degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (10, 11, 24, 25, 26, 27, 28, 29, 30)
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Specification