Delivery of analgesics through an inhalation route
First Claim
1. A condensation aerosol for delivery of a drug selected from the group consisting of acetaminophen, orphenadrine and tramadol, wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of acetaminophen, orphenadrine or tramadol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.
254 Citations
30 Claims
- 1. A condensation aerosol for delivery of a drug selected from the group consisting of acetaminophen, orphenadrine and tramadol, wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
-
4. A method of producing a drug selected from the group consisting of acetaminophen, orphenadrine and tramadol in an aerosol form comprising:
-
a. heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (5, 6, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
-
25. A condensation aerosol for delivery of acetaminophen, wherein the condensation aerosol is formed by heating a thin layer containing acetaminophen, on a solid support, to produce a vapor of acetaminophen, and condensing the vapor to form a condensation aerosol characterized by less than 5% acetaminophen degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
26. A condensation aerosol for delivery of orphenadrine, wherein the condensation aerosol is formed by heating a thin layer containing orphenadrine, on a solid support, to produce a vapor of orphenadrine, and condensing the vapor to form a condensation aerosol characterized by less than 5% orphenadrine degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
27. A condensation aerosol for delivery of tramadol, wherein the condensation aerosol is formed by heating a thin layer containing tramadol, on a solid support, to produce a vapor of tramadol, and condensing the vapor to form a condensation aerosol characterized by less than 5% tramadol degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
28. A method of producing acetaminophen in an aerosol form comprising:
-
a. heating a thin layer containing acetaminophen, on a solid support, to produce a vapor of acetaminophen, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% acetaminophen degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
-
29. A method of producing orphenadrine in an aerosol form comprising:
-
a. heating a thin layer containing orphenadrine, on a solid support, to produce a vapor of orphenadrine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% orphenadrine degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
-
30. A method of producing tramadol in an aerosol form comprising:
-
a. heating a thin layer containing tramadol, on a solid support, to produce a vapor of tramadol, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% tramadol degradation products by weight, and an MMAD of about 0.2 to 3 microns.
-
Specification