Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
First Claim
1. A coating for an implantable medical device, the coating comprising a polymer and an amino acid chemically bonded to the polymer, wherein the amino acid comprises L-arginine.
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Accused Products
Abstract
A coating for an implantable medical device is disclosed. The coating comprises a polymer and an amino acid chemically bonded, attached or conjugated to the polymer. In one embodiment, the coating can include a therapeutic substance. In lieu of bonding the amino acid to the polymer, the amino acid can be chemically bonded to the therapeutic substance or both the substance and the polymer. The amino acid can be polymers and/or oligomers of L-arginine, and copolymers of L-arginine with lysine. The coating can optionally include a nitric oxide donor, such as diazenium diolate type nitric oxide donors, chemically conjugated to the amino acid.
373 Citations
26 Claims
- 1. A coating for an implantable medical device, the coating comprising a polymer and an amino acid chemically bonded to the polymer, wherein the amino acid comprises L-arginine.
- 3. A coating for an implantable medical device, the coating comprising a polymer and an amino acid chemically bonded to the polymer, wherein the amino acid comprises polymers and/or oligomers of L-arginine, or copolymers or co-peptides of L-arginine with lysine.
- 12. A coating for an implantable medical device, the coating comprising a polymer, a therapeutic substance contained by the polymer for the sustained release of the therapeutic substance and an amino acid chemically bonded, attached or conjugated to the polymer, the therapeutic substance, or both, wherein the amino acid comprises L-arginine.
- 15. A coating for an implantable medical device, the coating comprising a polymer, a therapeutic substance contained by the polymer for the sustained release of the therapeutic substance and an amino acid chemically bonded, attached or conjugated to the polymer, the therapeutic substance, or both, wherein the amino acid comprises polymers and/or oligomers of L-arginine, or copolymers or co-peptides of L-arginine with lysine.
- 20. A method of coating an implantable medical device, comprising forming a coating on the device, the coating comprising a polymer and an amino acid chemically bonded, attached or conjugated to the polymer, wherein the amino acid comprises L-arginine.
- 22. A method of coating an implantable medical device, comprising forming a coating on the device, the coating comprising a polymer and an amino acid chemically bonded attached or conjugated to the polymer, wherein the amino acid comprises polymers and/or oligomers of L-arginine, or copolymers or co-peptides of L-arginine with lysine.
Specification