Guided mode resonant filter biosensor using a linear grating surface structure
DCFirst Claim
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1. A biosensor comprising:
- (a) a one-dimensional grating layer comprised of a material having a high refractive index;
(b) a low refractive index material layer that supports the one-dimensional grating layer; and
(c) one or more specific binding substances immobilized on the surface of the one-dimensional grating layer opposite of the low refractive index material layer;
wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free,wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
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Citations
13 Claims
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1. A biosensor comprising:
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(a) a one-dimensional grating layer comprised of a material having a high refractive index; (b) a low refractive index material layer that supports the one-dimensional grating layer; and (c) one or more specific binding substances immobilized on the surface of the one-dimensional grating layer opposite of the low refractive index material layer;
wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free,wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification