Apparatus and methods of brain shift compensation and applications of the same
First Claim
1. A method of compensation for intra-operative brain shift of a living subject, comprising the steps of:
- a. pro-operatively acquiring brain images of the living subject;
b. constructing a statistical atlas, [E], of brain displacements of the living subject from the pro-operatively acquired brain images, wherein [E] comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan and is in the form of an n×
m matrix with n, m being integers;
c. intra-operatively measuring brain displacements, {f}, of the living subject, wherein {f} is in the form of a n×
1 matrix;
d. deriving an intra-operative displacement atlas, [Xf], from the intra-operatively measured brain displacements {f} and the statistical atlas [E];
e. obtaining intra-operative brain shift at least from the intra-operative displacement atlas [Xf]; and
f. compensating for the intra-operative brain shift.
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Abstract
A method of compensation for intra-operative brain shift of a living subject. In one embodiment, the method includes the steps of pro-operatively acquiring brain images of the living subject, constructing a statistical atlas of brain displacements of the living subject from the pro-operatively acquired brain images, intra-operatively measuring brain displacements of the living subject, deriving an intra-operative displacement atlas from the intra-operatively measured brain displacements and the statistical atlas, obtaining intra-operative brain shift at least from the intra-operative displacement atlas, and compensating for the intra-operative brain shift.
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Citations
33 Claims
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1. A method of compensation for intra-operative brain shift of a living subject, comprising the steps of:
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a. pro-operatively acquiring brain images of the living subject; b. constructing a statistical atlas, [E], of brain displacements of the living subject from the pro-operatively acquired brain images, wherein [E] comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan and is in the form of an n×
m matrix with n, m being integers;c. intra-operatively measuring brain displacements, {f}, of the living subject, wherein {f} is in the form of a n×
1 matrix;d. deriving an intra-operative displacement atlas, [Xf], from the intra-operatively measured brain displacements {f} and the statistical atlas [E]; e. obtaining intra-operative brain shift at least from the intra-operative displacement atlas [Xf]; and f. compensating for the intra-operative brain shift. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system of compensation for intra-operative brain shift of a living subject, comprising:
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a. an imaging acquiring device for pro-operatively acquiring brain images of the living subject; b. a scanning device for intra-operatively measuring brain displacements of the living subject; and c. at least one computer coupled with the image acquiring device and the scanning device and adapted for performing the steps of; i). constructing a statistical atlas of brain displacements of the living subject from the pro-operatively acquired brain images, wherein the statistical atlas comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan; ii). deriving an intra-operative displacement atlas from the intra-operatively measured brain displacements and the statistical atlas; iii). obtaining intra-operative brain shift at least from the intra-operative displacement atlas; and iv). compensating for the intra-operative brain shift. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of compensation for intra-operative brain shift of a living subject, comprising the steps of:
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a. constructing a statistical atlas from pre-operatively acquired brain images of the living subject, wherein the statistical atlas comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan; b. calculating brain displacements of the living subject from the statistical atlas for a given set of the living subject'"'"'s orientation and amount of cerebrospinal fluid drainage; c. intra-operatively measuring brain displacements of the living subject; d. obtaining the intra-operative brain shift from the calculated brain displacements and the measured brain displacements; and e. compensating for the intra-operative brain shift. - View Dependent Claims (32, 33)
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Specification