Vitamin D derivatives
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Abstract
The object of the present invention is to provide a vitamin D derivative exhibiting excellent physiological activity as medicines, in particular as therapeutic agents for skin disease including psoriasis, and having decreased hypercalcemic activity.
The present invention provides vitamin D derivatives represented by the general Formula (1):
wherein
- in Formula (1), X is oxygen or sulfur;
- R1 is hydrogen or Formula (2)
-
- R2 is hydrogen or alkyl;
- R3 and R4 are hydrogen or alkyl or R3 and R4 together form a double bond between the 16- and 17-positions;
- R5 is hydrogen or —OR13 in which R13 is hydrogen or a protecting group; and
- R6 is hydrogen or a protecting group.
15 Citations
11 Claims
- 1. A vitamin D derivative of Formula (1):
Specification