Non-invasive diagnostic and monitoring method and apparatus based on odor detection

• US 7,076,371 B2
• Filed: 03/02/2002
• Issued: 07/11/2006
• Est. Priority Date: 03/03/2001
• Status: Active Grant

• Current Assignee: Chi Yung Fu
• Original Assignee: Chi Yung Fu
• Inventors: Fu, Chi Yung
• Primary Examiner(s): Brusca, John S.
• Application Number:
  US10/087,049
• Publication Number:
  US 20030008407A1
• Time in Patent Office: 1,592 Days
• Field of Search: 702/19, 702/22, 702/27, 436/1
• US Class Current: 702/19
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A set of volatile markers are determined which are characteristic of a particular condition or disease, and which will be found in the exhaled breath of a person or odor from other parts of a body or from an entity. These markers are detected in the breath odor or gaseous emanations from the body or entity noninvasively using a volatile substance detector of sufficient sensitivity, such as an artificial olfactory system. The detected marker data is processed in an artificial neural network/fuzzy filter system with an algorithm that intelligently adapts to the individual body or entity and also optionally (if necessary) with a correction algorithm to eliminate environmental and other erroneous contributions to the markers. Any number of markers may be used, depending on how well they correlate with the condition and how accurate a result is desired, i.e. general screening or accurate diagnosis and monitoring.

Claims

1. A method for determining a condition of an entity comprising:

selecting a set of volatile markers which are characteristic of a condition and which will be found in a gaseous emanation from the entity;

non-invasively detecting these volatile markers in the gaseous emanation from the entity;

processing the detected marker data in an artificial neural network that includes a fuzzy filter system.

2. The method for claim 1 further comprising further processing the detected marker data with a correction algorithm to eliminate environmental contributions to the markers.

3. The method of claim 1 wherein the volatile markers are detected using an artificial olfactory system.

4. The method of claim 1 wherein the detected marker data is processed with an algorithm which intelligently adapts to an individual entity.

5. The method of claim 1 wherein the entity is selected from the group consisting of living humans, other living animals or organisms, and non-living entities.

6. The method of claim 5 wherein the entity is a living human and the volatile markers are characteristic of a disease or other medical condition.

7. The method of claim 6 wherein the disease is selected from the group consisting of diabetes, cancer, mental illness,, ulcers, and HIV.

8. The method of claim 5 wherein the entity is food and the volatile markers are characteristic of food degradation.

9. The method of claim 1 wherein the markers are selected from supermarkers which correlate substantially with a single condition, and collective supermarkers which comprise of a set of secondary markers which individually correspond to more than one condition but collectively correspond to a single condition.

29. The method of claim 5 wherein the volatile markers are characteristic of E. Coli, H. Pylori, Salmonella, Staphylococcus aureus, or Bacillus anthracis.

10. A method for determining a disease or other medical condition of a person comprising:

selecting a set of volatile markers which are characteristic of the disease or other medical condition and which will be found in the exhaled breath or other gaseous emanation from the person;

non-invasively detecting these volatile markers in the exhaled breath or other gaseous emanation from the person;

processing the detected marker data in an artificial neural network that includes a fuzzy filter system.

11. The method of claim 10 wherein the volatile markers are detected using an artificial olfactory.

12. The method of claim 11 wherein the detected marker data is processed with an algorithm adapted to an individual person by training the neural network with calibration data from the person.

13. The method of claim 10 further comprising further processing the detected marker data with a correction algorithm to eliminate environmental contributions to the markers.

14. The method of claim 13 wherein the environmental correction of detected markers is performed by fitting a minimum of three measured points to a pre-established wash-out curve for each marker.

15. The method of claim 10 wherein the disease is diabetes and the markers are selected to measure the destruction or deterioration of islet cells.

16. The method of claim 10 wherein the disease is diabetes and the markers are selected to measure the destruction or deterioration of cell membranes by lipid peroxidation or protein oxidation.

17. The method of claim 16 wherein the markers are used to predict a rise in glucose preceding the actual rise in glucose.

18. The method of claim 16 wherein the cell membranes are erythrocyte cell membranes.

19. The method of claim 15 wherein the markers are used to detect an overeating condition.

20. The method of claim 16 wherein the markers are selected from the group consisting of:

carbon dioxide (CO₂), acetone (CH₃COCH₃), hydrogen peroxide (H₂O₂), ethane (C₂H₆), ethanol, pentane (C₅H₁₂ or methylbutane), pentanol, isoprene (C₅H₈, 2-methylbuta-1,3-diene), hexanal (C₆H₁₂O or caproaldehyde or n-capric aldehyde), propanol (C₃H₆O or propional or propionaldehyde), pentanal (C₅H₁₀O or valeral or valeraldehyde), butanal (C₄H₈O or butyraldehyde), 2-methylpropene(C₄H₈ or isobutene or i-butene), 2-octenal, 2-nonenal, 2-heptenal, 2-hexenal, 2,4-decadienal, 2,4-nonadienal, methyl 2,3-dihydroindene (C₁₀H₁₂), dimethylnaphthalene (C₁₂H₁₂), alkylbenzene (C₁₅H₂₄), n-propylheptane (C₁₀H₂₂), n-octadecane (C₁₈H₃₈), n-nonadecane (C₁₉H₄₀), hexadiene (C₆H₁₀), cresol (C₇H₈O), sabinene (C₁₀H₁₆), methyl heptanol (C₈H₁₈O), methyl ethyl pentanol (C₈H₁₈O), trimethylpentanol (C₈H₁₈O or ethylhexanol or isooctanol), decanol (C₁₀H₂₂O), dodecanol (C₁₂H₂₆O), and alkyl dioxolane (C₆H₁₂O₂).

21. The method of claim 10 wherein the markers are selected to measure the effect of an increase of free radicals over a normal level wherein the increase of free radicals is related to the disease or other medical condition.

22. Apparatus for detecting the condition of an entity comprising:

a volatile marker detector for non-invasively detecting a set of markers which are characteristic of a condition and which will be found in a gaseous emanation from the entity;

an artificial neural network for processing detected volatile marker data and including fuzzy filters associated with at least one of the input layer and a hidden layer of the artificial neural network.

23. The apparatus of claim 22 wherein the volatile marker detector is an artificial olfactory system.

24. The apparatus of claim 23 wherein the artificial neural network includes an algorithm adapted to the individual entity.

25. The apparatus of claim 22 wherein the volatile marker detector is positioned in or connected to a microwave oven.

26. The apparatus of claim 22 further comprising a heater operatively connected to the volatile marker detector to refresh the detector.

27. The apparatus of claim 26 wherein the detector comprises an array of sensors, and the heater is connected to either the array or to individual sensors.

28. The apparatus of claim 22 wherein the artificial neural network comprises an input layer, an output layer and at least two hidden layers between the input and output layers, each layer comprising a plurality of nodes, wherein the nodes of at least the second hidden layer comprise fuzzy filters.