Ventilatory assistance for treatment of cardiac failure and Cheyne-Stokes breathing

• US 7,077,132 B2
• Filed: 06/11/2004
• Issued: 07/18/2006
• Est. Priority Date: 05/22/1998
• Status: Expired due to Term

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Berthon-Jones, Michael
• Primary Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US10/865,944
• Publication Number:
  US 20040237963A1
• Time in Patent Office: 767 Days
• Field of Search: 128/200.24, 128/204.18, 128/204.21, 128/204.22, 128/204.23, 128/204.24, 128/204.26, 128/204.29, 128/205.11, 600/529, 600/532, 600/533, 600/538
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/0858 Pressure sampling ports
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2230/42 Rate

Abstract

Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support, for example positive pressure ventilatory support using a blower and mask. Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation (for example half the absolute value of the respiratory airflow) and a measure of longterm average ventilation (for example the instantaneous ventilation low pass filtered with a 100 second time constant). A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. Clipping is typically to between half and double the degree of support that would do all the respiratory work. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject'"'"'s respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.

Claims

1. A method for treatment of Cheyne-Stokes breathing during the provision of ventilatory support comprising the steps of:

delivering a controlled supply of breathable gas at a pressure above atmospheric to a subject to provide the subject with ventilatory support during an inspiratory portion and an expiratory portion of a respiratory cycle of the subject;

deriving a measure of respiratory airflow from the subject;

selecting a ventilatory support target measure to oppose a Cheyne-Stokes pattern of breathing, said ventilatory support target measure being determined as a function of the measure of respiratory airflow; and

modulating the degree of ventilatory support as a function of said ventilatory support target measure and said measure of respiratory airflow,

wherein said ventilatory support counteracts a Cheyne Stokes waxing-waning pattern of breathing by changing pressure levels in the inspiratory portion and the expiratory portion, said changing pressure levels varying from previous pressure levels delivered in a previous inspiratory portion and a previous expiratory portion of a previous respiratory cycle of the subject.

2. The method of claim 1 wherein said degree of ventilatory support is a function of a comparison between said ventilatory support target measure and a further measure derived as a function of respiratory airflow.

3. The method of claim 2 wherein said further measure is derived on a time scale of less than a single breath.

4. The method of claim 3 wherein said ventilatory support target measure is a measure of ventilation.

5. The method of claim 4 wherein said further measure is instantaneous ventilation.

6. An apparatus for the treatment of Cheyne-Stokes breathing comprising:

means for providing a breathable gas at a controllable pressure above atmospheric to a subject;

means for deriving a flow signal indicative of a measure of respiratory airflow of the subject; and

a controller to run said means for providing a breathable gas in response to said flow signal, wherein said controller comprises programmed instructions for execution by said controller, said instructions controlling steps of;

delivering ventilatory support during an inspiratory portion and an expiratory portion of a respiratory cycle to the subject;

determining a ventilatory support target measure as a function of the flow signal, said ventilatory support target measure being selected to oppose a Cheyne-Stokes pattern of breathing; and

modulating the degree of ventilatory support to counteract a Cheyne-Stokes waxing-waning pattern of breathing by changing pressure levels in the inspiratory portion and the expiratory portion, said changing pressure levels varying from previous pressure levels delivered in a previous inspiratory portion and a previous expiratory portion of a previous respiratory cycle of the subject.

7. The apparatus of claim 6 wherein said degree of ventilatory support is a function of a comparison between said ventilatory support target measure and a further measure derived as a function of said flow signal.

8. The apparatus of claim 7 wherein said further measure is derived on a time scale of less than a single breath.

9. The apparatus of claim 8 wherein said ventilatory support target measure is a measure of ventilation.

10. The apparatus of claim 9 wherein said further measure is instantaneous ventilation.

11. A method for treatment of Cheyne-Stokes breathing during the provision of ventilatory support comprising the steps of:

delivering a controlled supply of breathable gas at a pressure above atmospheric to a subject;

deriving a measure of respiratory airflow from the subject;

selecting a ventilatory support target measure to oppose a Cheyne-Stokes pattern of breathing, said ventilatory support target measure being determined as a function of the measure of respiratory airflow; and

deriving an input value from said measure of respiratory airflow, said input value being derived during a time period less than that of one breath; and

changing the degree of ventilatory support provided by said delivering step to counteract a Cheyne-Stokes waxing-waning pattern of breathing as a function of said ventilatory support target measure and said input value.

12. The method of claim 11 wherein said time period is about several seconds.

13. The method of claim 12 wherein said degree of ventilatory support is dependent on a further function of said measure of respiratory airflow.

14. The method of claim 13 wherein said further function is an estimation of respiratory phase of the subject.

15. The method of claim 14 wherein said estimation of respiratory phase provides a continuous phase variable calculated from a fuzzy logic process.

16. The method of claim 15 wherein said ventilatory support target measure is about 95% of an average inspired volume and said input value is instantaneous ventilation.

17. Apparatus for the treatment of Cheyne-Stokes breathing comprising:

means for providing a breathable gas at a controllable pressure above atmospheric to a subject;

means for deriving a flow signal indicative of a measure of respiratory airflow of the subject; and

a controller to operate said means for providing a breathable gas in response to said flow signal, wherein said controller comprises programmed instructions for execution by said controller, said instructions controlling the steps of;

delivering a controlled supply of breathable gas at a pressure above atmospheric to the subject;

calculating a ventilatory support target measure as a function of the flow signal to oppose a Cheyne-Stokes pattern of breathing;

calculating an input value from said flow signal, said input value being derive during a time period less than that of one breath; and

adjusting the degree of ventilatory support provided by said delivering step to counteract a Cheyne-Stokes waxing-waning pattern of breathing as a function of said ventilatory support target measure and said input value.

18. The apparatus of claim 17 wherein said time period is about several seconds.

19. The apparatus of claim 18 wherein said degree of ventilatory support is dependent on a further function of said flow signal.

20. The apparatus of claim 19 wherein said further function is an estimation of respiratory phase of the subject.

21. The apparatus of claim 20 wherein said estimation of respiratory phase provides a continuous phase variable calculated from a fuzzy logic process.

22. The apparatus of claim 21 wherein said ventilatory support target measure is about 95% of an average inspired volume and said input value is instantaneous ventilation.