System for measuring and analyzing vasodilatation index

• US 7,077,809 B2
• Filed: 05/07/2004
• Issued: 07/18/2006
• Est. Priority Date: 05/21/2003
• Status: Active Grant

• Current Assignee: Hsien-Tsai Wu
• Original Assignee: Hsien-Tsao Wu
• Inventors: Chi, Chih-Kai, Wu, Hsien-Tsai, Chen, Yung-Kang
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/840,648
• Publication Number:
  US 20040254485A1
• Time in Patent Office: 802 Days
• Field of Search: 600500-504, 600/507, 600322-324, 600/335, 600/336, 600/490, 600492-497
• US Class Current: 600/490
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

In a vasodilatation index measuring and analyzing system, a measuring unit includes a measuring device for measuring standard and comparative pulses of a digit of a subject in relaxed and comparative states, respectively. An external pressure is applied to a limb part of the subject to occlude blood flow to the digit following measurement of the standard pulse. The comparative pulse is measured upon release of the external pressure. A pre-processing unit is coupled to the measuring unit for filtering noise from and digitizing the standard and comparative pulses obtained by the measuring device. An analyzing unit is coupled to the pre-processing unit for calculating standard and comparative pulse areas of at least one cycle of the standard and comparative pulses processed by the pre-processing unit, respectively, and for subsequently calculating a pre-defined index related to a difference between the standard and comparative pulse areas.

Claims

1. A vasodilatation index measuring and analyzing system, comprising:

a constricting unit configured to apply external pressure to a limb of a subject to occlude flow of blood to a first digit of the subject;

a measuring unit including a first measuring device configured to measure a standard pulse of the first digit of the subject, the standard pulse being measured before the application of external pressure from the constricting unit, and further configured to measure comparative pulse of the first digit of the subject, the comparative pulse being measured after release of the external pressure from the constricting unit, said standard and comparative pulses being measured for at least one cycle of application and release of said pressure;

a pre-processing unit, coupled to said measuring unit, configured to filter noise from the standard and comparative pulse measurements obtained by the first measuring device and further configured to digitize the standard and comparative pulse measurements; and

an analyzing unit, coupled to said pre-processing unit, wherein the analyzing unit calculates a standard and comparative pulse area of said at least one cycle of the standard and comparative pulse measurements digitized by said pre-processing unit and calculates a pre-defined index based on a difference between the standard and comparative pulse areas.

2. The vasodilatation index measuring and analyzing system according to claim 1, wherein said first measuring device measures the standard and comparative pulses of the first digit by emitting and receiving an optical signal through the first digit.

3. The vasodilatation index measuring and analyzing system according to claim 2, wherein the optical signal is infrared light.

4. The vasodilatation index measuring and analyzing system according to claim 1, wherein said analyzing unit calculates the pre-defined vasodilatation index according to the following equation:

[(comparative pulse area−

standard pulse area)/standard pulse area]×

100%.

5. The vasodilatation index measuring and analyzing system according to claim 1, wherein said measuring unit further includes a second measuring device configured to measure a standard pulse and a comparative pulse of a second digit of the subject simultaneously with the measuring operation of said first measuring device, said pre-processing unit filtering noise from and digitizing the standard and comparative pulses obtained by said second measuring device, a distance between the first digit and the second digit being defined as a distance measured along a body of the subject between the first digit and the second digit, corresponding positions on pulse waveforms of the first and second digits being defined as positions on the pulse waveforms respectively obtained by said first and second measuring devices at the same point of a cardiac cycle of the subject, and a time difference being defined as a difference in time between the corresponding positions, wherein said analyzing unit performs a calculation based on the following equation:

distance between the first digit and the second digit/(a time difference between corresponding positions on pulse waveforms of the first and second digits obtained respectively by said first and second measuring devices).

6. The vasodilatation index measuring and analyzing system according to claim 5, wherein the corresponding positions on the respective waveforms are pacemaker positions.

7. The vasodilatation index measuring and analyzing system according to claim 5, wherein the corresponding positions on the respective waveforms are peak positions.

8. A vasodilatation index measuring and analyzing system, comprising:

a constricting unit configured to apply external pressure to a limb of a subject to occlude flow of blood to a first digit of the subject;

a measuring unit including a first measuring device configured to measure a standard pulse of the first digit of the subject, the standard pulse being measured before the application of external pressure from the constricting unit, and further configured to measure a comparative pulse of the first digit of the subject after release of the external pressure from the constricting unit, said standard and comparative pulses being measured for at least one cycle of application and release of said pressure;

a pre-processing unit, coupled to said measuring unit, configured to filter noise from the standard and comparative pulse measurements obtained by the first measuring device and further configured to digitize the standard and comparative pulse measurements; and

an analyzing unit, coupled to said pre-processing unit, wherein the analyzing unit calculates a first pre-defined vasodilatation index based on the standard and comparative pulse measurements.

9. The vasodilatation index measuring and analyzing system according to claim 8, wherein said first measuring device measures the standard and comparative pulses of the first digit by emitting and receiving an optical signal through the first digit.

10. The vasodilatation index measuring and analyzing system according to claim 8, wherein the optical signal is infrared light.

11. The vasodilatation index measuring and analyzing system according to claim 8, wherein the analyzing unit calculates a standard and a comparative pulse area of at least one cycle of the standard and comparative pulse measurements digitized by the pre-processing unit, and wherein the first pre-defined vasodilatation index is based on a difference between the standard and the comparative pulse areas.

12. The vasodilatation index measuring and analyzing system according to claim 11, wherein the first pre-defined vasodilatation index is calculated according to the following formula:

[(comparative pulse area standard pulse area)/standard pulse area]×

100%.

13. The vasodilatation index measuring and analyzing system according to claim 8, wherein the measuring unit further includes a second measuring device configured to measure a standard pulse and a comparative pulse of a second digit of the subject simultaneously with the measuring operation of the first measuring device, and wherein said pre-processing unit further filters noise from and digitizes the standard and comparative pulses obtained by said second measuring device, a distance between the first digit and the second digit being measured along a body of the subject between the first digit and the second digit, corresponding positions on a first pulse waveform of the first digit and a second pulse waveform of the second digit being positions on the pulse waveforms respectively obtained by said first and second measuring devices at a same point of a cardiac cycle of the subject, and a time difference being a difference in time between the corresponding positions on the first and second pulse waveforms, wherein the analyzing unit calculates a second pre-defined vasodilatation index based on the following formula:

distance between the first digit and the second digit/(a time difference between corresponding positions on pulse waveforms of the first and second digits obtained respectively by said first and second measuring devices).

14. The vasodilatation index measuring and analyzing system according to claim 13, wherein the corresponding positions on the first and the second pulse waveforms are pacemaker positions.

15. The vasodilatation index measuring and analyzing system according to claim 13, wherein the corresponding positions on the first and the second pulse waveforms are peak positions.