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Ultrasound imaging and treatment

  • US 7,078,015 B2
  • Filed: 11/08/2004
  • Issued: 07/18/2006
  • Est. Priority Date: 12/22/1989
  • Status: Expired due to Fees
First Claim
Patent Images

1. A method for an ultrasound treatment of a patient in need of such treatment, comprising administering, intra-arterially, to said patient a composition comprising stabilized gas bubbles and a therapeutic agent, and applying ultrasound, to treat said patient, wherein the stabilized gas bubbles are formed by a gas or a gas precursor selected from a group consisting of perfluoropropane;

  • perfluorobutane;

    perfluoropentane;

    perfluorohexane;

    perfluorocyclobutene;

    perfluoro-1-butene;

    perfluoro-2-butene;

    perfluoro-2-butyne;

    perfluoropropylene, hexafluoro acetone;

    isopropyl acetylene;

    allene;

    tetrafluoroallene;

    boron trifluoride;

    1,2-butadiene;

    1,3-butadiene;

    1,2,3-trichloro-2-fluoro-1,3-butadiene;

    2-methyl-1,3 butadiene;

    hexafluoro-1,3-butadiene;

    butadiyne;

    1-fluoro-butane;

    2-methyl-butane;

    1-butene;

    2-butene;

    2-methy-1-butene;

    2-methyl-2-butene;

    3-methyl-1-butene;

    1,4-phenyl-3-butene-2-one;

    2-methyl-1-butene-3-yne;

    butyl nitrate;

    1-butyne;

    2-butyne;

    2-chloro-,1,1,4,4,4-hexafluoro-butyne;

    3-methyl-1-butyne;

    2-bromo-butyraldehyde;

    carbonyl sulfide;

    crotononitrile;

    cyclobutane;

    methyl-cyclobutane;

    3-chloro-cyclopentene;

    cyclopropane;

    1,2-dimethyl-cyclopropane;

    1,1-dimethyl cyclopropane;

    1,2-dimethyl cyclopropane;

    ethyl cyclopropane;

    methyl cyclopropane;

    diacetylene;

    3-ethyl-3-methyl diaziridine;

    1,1,1-trifluorodiazoethane;

    dimethyl amine;

    hexafluoro-dimethyl amine;

    dimethylethylamine;

    bis-(dimethylphosphine)amine;

    2,3-dimethyl-2-norbomane;

    perfluorodimethylamine;

    dimethyloxonium chloride;

    1,3-dioxolane-2-one;

    1,1-dichloroethane;

    1,1-dichloro-1,2,2,2-tetrafluoro ethane;

    1,2-difluoro ethane;

    2-chioro-1,1-difluoroethane;

    2-chloro-1,1-difluoroethane;

    1-chloro-1,1,2,2-tetrafluoroethane;

    chloroethane;

    chioropentafluoro ethane;

    dichlorotrifluoroethane;

    fluoroethane;

    nitropentafluoro ethane;

    nitrosopentafluoro ethane;

    perfluoro ethylamine;

    ethyl vinyl ether;

    1,1-dichloroethylene;

    1,2-difluoroethylene;

    1,1-dichloro-1,2-difluoro ethylene;

    trifluoromethane sulfonyl chloride;

    trifluoro tethanesulfonyl fluoride;

    trifluoropentafluorothio methane;

    bromodifluoronitrosomethane;

    bromofluoromethane;

    bromochiorofluoromethane;

    trifluorobromomethane;

    chiorodifluoronitromethane;

    chiorodinitromethane;

    chiorofluoromethane;

    difluorodibromomethane;

    fluorodichioromethane;

    difluoromethane;

    difluorojodomethane;

    disilanomethane;

    fluoromethane;

    iodomethane;

    jodotrifluoromethane;

    octafluorocyclobutane;

    octafluoro-2-butene;

    octafluorocyclopentene;

    trifluoronitromethane;

    trifluoronitrosomethane;

    trichiorofluoromethane;

    trifluoromethane sulfonyichioride;

    2-methylbutane;

    methyl ether;

    methyl isopropyl ether;

    methyl lactate;

    methyl nitrite;

    methyl sulfide;

    methyl vinyl ether;

    neon;

    neopentane;

    nitrous oxide;

    1,2,3-nonadecanetricarboxylic acid-2-hydroxytrimethylester;

    1-nonene-3-yne;

    1,4-pentadiene;

    n-pentane;

    4-amino-4-methyl-2-pentanone;

    1-pentene;

    2-pentene (cis);

    2-pentene (trans);

    3-bromo-1-pentene;

    tetrachloro phthalic acid;

    2,3,6-trimethyl-piperidine;

    propane, 1,2-epoxy-propane;

    2,2-difluoro-propane;

    2-amino-propane, 2-chloro-propane;

    heptafluoro-1-nitro-propane;

    heptafluoro-1-nitroso-propane;

    propene;

    1-chloro-propylene;

    2-chloro-propylene;

    3-fluoro-propylene-propyne;

    3,3,3-trifluoro-propyne;

    3-fluoro-styrene;

    sulfur hexafluoride;

    2,4-diamino-sulfurdecafluoro-toluene;

    trifluoroacetonitrile;

    trifluoromethyl peroxide;

    trifluoromethyl sulfide;

    tungsten hexafluoride;

    vinyl acetylene;

    vinyl ether; and

    combinations thereof.

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