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Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors

  • US 7,078,180 B2
  • Filed: 08/30/2002
  • Issued: 07/18/2006
  • Est. Priority Date: 09/05/2001
  • Status: Active Grant
First Claim
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1. A method of diagnosing a cancer or a tumor in a mammal, said method comprisinga) obtaining a biological sample from said mammal;

  • b) contacting said sample with a composition comprising one or more ZEB specific detection reagent in an amount effective to permit detection and quantitation of a ZEB polypeptide, if present, in said sample, wherein said ZEB polypeptide is selected from the group consisting of SEQ ID NO;

    10, the amino acid sequence encoded by nucleotides 2537 to 3473 of SEQ ID NO;

    9, and the amino acid sequence encoded by nucleotides 481 to 1132 of SEQ ID NO;

    9;

    c) determining from b) one or more of the amount and the sub-cellular location of said ZEB polypeptide; and

    d) determining from c) altered expression levels and/or localization of said ZEB polypeptide relative to normal control samples, thereby diagnosing a cancer or a tumor in said mammal.

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