Methods for manipulating moieties in microfluidic systems
First Claim
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1. A method for manipulating a moiety in a microfluidic application, which method comprises:
- a) coupling a moiety to be manipulated onto a surface of a binding partner of said moiety to form a moiety-binding partner complex; and
b) manipulating said moiety-binding partner complex with a physical force in a microfluidic application chip format, wherein said manipulation is effected through a combination of a signal source that is external to said chip and a structure that is built into or on said chip, thereby said moiety is manipulated, and wherein said moiety is not directly manipulatable by an acoustic force and the moiety-binding partner complex is manipulated by an acoustic force.
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Abstract
This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.
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Citations
46 Claims
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1. A method for manipulating a moiety in a microfluidic application, which method comprises:
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a) coupling a moiety to be manipulated onto a surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a microfluidic application chip format, wherein said manipulation is effected through a combination of a signal source that is external to said chip and a structure that is built into or on said chip, thereby said moiety is manipulated, and wherein said moiety is not directly manipulatable by an acoustic force and the moiety-binding partner complex is manipulated by an acoustic force. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A kit for manipulating a moiety in a microfluidic application, which kit comprises:
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a) a binding partner onto the surface of which a moiety to be manipulated can be coupled to form a moiety-binding partner complex; b) means for coupling said moiety onto the surface of said binding partner; and c) a chip on which said moiety-binding partner complex can be manipulated with a physical force that is effected through a combination of a signal source that is external to said chip and a structure that is built into or on said chip, and wherein said moiety is not directly manipulatable by an acoustic force and the moiety-binding partner complex is manipulated by an acoustic force. - View Dependent Claims (46)
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Specification